- Lewis Chodosh, University of Pennsylvania
Howell and colleagues from the BCC risk-and-prevention panel report on how adding new, but available, information to current risk models could ultimately better predict a woman’s individual breast cancer risk.
The publicity surrounding actress Angelina Jolie’s decision to undergo genetic testing for the BRCA1 gene and subsequently a risk reducing mastectomy has resulted in an increase of referrals to clinics in the UK.
Digitized mammographic images contain computer-extractable information of the parenchymal pattern not captured during routine radiologic interpretation, which have the potential to distinguish between BRCA1/2 mutation carriers and non-carriers.
A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging.
Chang, Perez, and colleagues, review recent data on different combinations of anti-human epidermal growth factor receptor (HER2) treatments, as part of the ‘recent advances in breast cancer treatment’ special series.
Rots and colleagues describe aberrant DNA methylation and histone modifications as two important classes of epigenetic mutations in breast cancer and review the preclinical and clinical epigenetic-based therapies currently being explored.
From the blog
- 19 September 2014
- The Jolie effect – increasing options for patients
Aims & scope
Breast Cancer Research is an international, peer-reviewed online journal, publishing original research, reviews, editorials and reports. Open access research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal publishes preclinical, translational and clinical studies with a biological basis, including Phase I and Phase II trials.
Carmen Criscitiello, Angela Esposito, Lucia Gelao, Luca Fumagalli, Marzia Locatelli, Ida Minchella, Laura Adamoli, Aron Goldhirsch, Giuseppe CuriglianoBreast Cancer Research 2014, 16:204 (25 February 2014)
- 19 September 2014
- Health news of high-profile celebrities 'has long-term effects for public health care'
- 01 September 2014
- Metastasis more likely to occur with clusters of circulating tumor cells rather than single cells
- 12 August 2014
- Signals regulating mammary stem cell activation during pregnancy can be hijacked by breast cancer cells