- Lewis Chodosh, University of Pennsylvania
Digitized mammographic images contain computer-extractable information of the parenchymal pattern not captured during routine radiologic interpretation, which have the potential to distinguish between BRCA1/2 mutation carriers and non-carriers.
A self-reported lack of physical activity was associated with shortened telomere length in early stage breast cancer survivors, suggesting a mechanism by which exercise can reduce cellular aging.
Chang, Perez, and colleagues, review recent data on different combinations of anti-human epidermal growth factor receptor (HER2) treatments, as part of the ‘recent advances in breast cancer treatment’ special series.
Rots and colleagues describe aberrant DNA methylation and histone modifications as two important classes of epigenetic mutations in breast cancer and review the preclinical and clinical epigenetic-based therapies currently being explored.
An updated pathological definition of breast cancer molecular subtypes is proposed that may maximise the number of patients classifiable as “Luminal-A like” and decrease the number for whom cytotoxic therapy is generally recommended.
Five serum proteins can distinguish between serum from women with breast cancer and healthy control subjects with high sensitivity and specificity and can significantly predict recurrence-free survival in women with estrogen receptor negative tumors.
From the blog
Aims & scope
Breast Cancer Research is an international, peer-reviewed online journal, publishing original research, reviews, editorials and reports. Open access research articles of exceptional interest are published in all areas of biology and medicine relevant to breast cancer, including normal mammary gland biology, with special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal publishes preclinical, translational and clinical studies with a biological basis, including Phase I and Phase II trials.
All reviews, commentaries and reports published in Breast Cancer Research become free to access 6 months after publication. See below for the latest free review.
Kara N Maxwell, Katherine L NathansonBreast Cancer Research 2013, 15:212
(20 December 2013)
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