Targeting CCL21-CCR7 signaling in breast cancer

MicroRNA let-7a binds directly to the 3'UTR of C-C chemokine receptor type 7 (CCR7), blocking its protein expression and suppressing migration and invasion of breast cancer cells.

Breast cancer screening, prognosis and survival

Patients with breast cancer detected in mammography screening have a more favorable prognosis than those diagnosed outside a screening program and this should be taken into account in order to avoid over-treatment of screen-detected patients.

Genetic variation in triple negative breast cancer

Potential geographic and ethnic variations in the prevalence of EGFR mutations in triple negative breast cancer have implications for clinical trial design for anti-estrogen growth factor receptor (EGFR) therapies.

HER2 blockade in breast cancer

Combined lapatinib and trastuzumab therapy may improve outcomes in patients with human epidermal growth factor 2 (HER2)-positive breast cancer; adding estrogen receptor inhibition may be optimal in some patients.

Nanotechnology in breast cancer detection

Antibody-conjugated magnetic nanoparticles and superconducting quantum interference device sensors may provide a useful, viable and highly-sensitive alternative to mammographic screening in breast tumor cell detection.

Tissue density in breast cancer probability

When studying the relationship between breast dense area and breast cancer risk, adjustments for non-dense tissue may give more valid results than adjustment for BMI.