Nodal: prognostic breast cancer biomarker?

The embryonic morphogen Nodal is associated with advanced stage invasive human breast cancer, and may have a role as both a prognostic biomarker and a therapeutic target.

CENP-A marker for breast cancer relapse

The essential centromere protein, CENP-A, is a strong prognostic marker for distant relapse in estrogen-receptor positive breast cancer not treated with systemic therapy, and may contribute to disease progression.

Cellular 'glue' resists breast cancer

The protein Perp, associated with desmosomes - the glue that sticks cells together - is involved in suppressing breast cancer and provides a potential new target for future treatment.

Vitamin D receptor and breast cancer

Genetic variations in the vitamin D receptor and CYP24A1, an enzyme responsible for deactivating vitamin D, are associated with an increase in breast cancer risk for African American women.

Breastfeeding and breast cancer

Breastfeeding is protective against BRCA1- but not BRCA2-associated breast cancer, suggesting they have different biological pathways for carcinogenesis, and mutation carriers should be advised of the potential benefit of breastfeeding.

Pre-visit education for genetic counselling

Pre-counselling education by means of a website could lead to more effective first visits for breast cancer genetic counselling by improving counselees ability to recall information they are given in the consultation.