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Volume 10 Issue 1
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Comment |
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Prognostic ability of a panel of immunohistochemistry markers – retailoring of an 'old solution'
Donal J Brennan, William M Gallagher Breast Cancer Research 2008, 10:102 (25 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The role of single nucleotide polymorphisms in breast cancer metastasis
James M Rae, Todd C Skaar, Susan G Hilsenbeck, Steffi Oesterreich Breast Cancer Research 2008, 10:301 (18 January 2008)
Abstract | Full text | PDF | PubMed
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Re-evaluating early breast neoplasia
Sharon Moulis, Dennis C Sgroi Breast Cancer Research 2008, 10:302 (8 February 2008)
Abstract | Full text | PDF | PubMed
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Fatal attraction: why breast cancer cells home to bone
Lorenz C Hofbauer, Tilman Rachner, Shiv K Singh Breast Cancer Research 2008, 10:101 (25 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Review |
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Mammographic density. Potential mechanisms of breast cancer risk associated with mammographic density: hypotheses based on epidemiological evidence
Lisa J Martin, Norman F Boyd Breast Cancer Research 2008, 10:201 (9 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Sugar and fat – that's where it's at: metabolic changes in tumors
Christian D Young, Steven M Anderson Breast Cancer Research 2008, 10:202 (20 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Re-evaluation of mammary stem cell biology based on in vivo transplantation
Gilbert H Smith, Daniel Medina Breast Cancer Research 2008, 10:203 (25 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Research |
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Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells
Yuchao Gu, Junhua Zhang, Wenyi Mi, Jing Yang, Feng Han, Xinzhi Lu, Wengong Yu Breast Cancer Research 2008, 10:R1 (3 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients
Andrea Sassen, Justine Rochon, Peter Wild, Arndt Hartmann, Ferdinand Hofstaedter, Stephan Schwarz, Gero Brockhoff Breast Cancer Research 2008, 10:R2 (8 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Clinical significance of Akt and HER2/neu overexpression in African-American and Latina women with breast cancer
Yanyuan Wu, Hezla Mohamed, Ram Chillar, Ishrat Ali, Sheila Clayton, Dennis Slamon, Jaydutt V Vadgama Breast Cancer Research 2008, 10:R3 (10 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Activated Akt (pAkt) overexpression in tumours predicts a lower survival rate in African American and Latina women, suggesting pAkt is a potential therapeutic target for these high risk populations.
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Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells
Fabrice Journé, Naïma Kheddoumi, Carole Chaboteaux, Hugues Duvillier, Guy Laurent, Jean-Jacques Body Breast Cancer Research 2008, 10:R4 (11 January 2008)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Calcium released during the process of bone resorption may enhance the antitumour effects of bisphosphonates and increase their therapeutic activity in women being treated for skeletal complications related to breast cancer.
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Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
Yong Pan, Edward J Weinman, Jia Le Dai Breast Cancer Research 2008, 10:R5 (11 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Can clinically relevant prognostic subsets of breast cancer patients with four or more involved axillary lymph nodes be identified through immunohistochemical biomarkers? A tissue microarray feasibility study
Simon J Crabb, Chris D Bajdik, Samuel Leung, Caroline H Speers, Hagen Kennecke, David G Huntsman, Karen A Gelmon Breast Cancer Research 2008, 10:R6 (14 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Derlin-1 is overexpressed in human breast carcinoma and protects cancer cells from endoplasmic reticulum stress-induced apoptosis
Jiao Wang, Hui Hua, Yuliang Ran, Hongyin Zhang, Weiping Liu, Zhihua Yang, Yangfu Jiang Breast Cancer Research 2008, 10:R7 (20 January 2008)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Overexpression of derlin-1, a protein which relieves endoplasmic reticulum stress-induced apoptosis, in breast carcinomas suggests regulation of the stress response pathway may be critical in the development and progression of breast cancer.
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Intrauterine environments and breast cancer risk: meta-analysis and systematic review
Sue Park, Daehee Kang, Katherine A McGlynn, Montserrat Garcia-Closas, Yeonju Kim, Keun Yoo, Louise A Brinton Breast Cancer Research 2008, 10:R8 (21 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The combined immunodetection of AP-2α and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors
Abdelkader Allouche, Gregory Nolens, Annalisa Tancredi, Laurence Delacroix, Julie Mardaga, Viviana Fridman, Rosita Winkler, Jacques Boniver, Philippe Delvenne, Dominique Y Begon Breast Cancer Research 2008, 10:R9 (24 January 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Brca1 breast tumors contain distinct CD44+/CD24- and CD133+ cells with cancer stem cell characteristics
Mollie H Wright, Anna Calcagno, Crystal D Salcido, Marisa D Carlson, Suresh V Ambudkar, Lyuba Varticovski Breast Cancer Research 2008, 10:R10 (1 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Brca1-deficient mouse mammary tumours harbour heterogeneous cancer stem cell populations and CD44+/24- cells also identify human breast cancer stem cells; spheroid-forming assay may allow rapid screening of tumours for stem cell enrichment.
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Suppression of adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo
Ji-Young Jang, Yun Choi, Yoon-Kyung Jeon, Chul-Woo Kim Breast Cancer Research 2008, 10:R11 (12 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype
Cameron Snell, Michael Krypuy, Ee Wong, kConFab investigators, Maurice B Loughrey, Alexander Dobrovic Breast Cancer Research 2008, 10:R12 (12 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study
Vanessa Dumeaux, Anne-Lise Børresen-Dale, Jan-Ole Frantzen, Merethe Kumle, Vessela N Kristensen, Eiliv Lund Breast Cancer Research 2008, 10:R13 (13 February 2008)
Abstract | Full text | PDF | PubMed
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Breast cancer stroma frequently recruits fetal derived cells during pregnancy
Gil Dubernard, Sélim Aractingi, Michel Oster, Roman Rouzier, Marie-Christine Mathieu, Serge Uzan, Kiarash Khosrotehrani Breast Cancer Research 2008, 10:R14 (13 February 2008)
Abstract | Full text | PDF | PubMed
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ESR1 and EGF genetic variation in relation to breast cancer risk and survival
Kristjana Einarsdóttir, Hatef Darabi, Yi Li, Yen Low, Yu Li, Carine Bonnard, Arvid Sjölander, Kamila Czene, Sara Wedrén, Edison T Liu, Per Hall, Keith Humphreys, Jianjun Liu Breast Cancer Research 2008, 10:R15 (14 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A single nucleotide polymorphism genotyping study shows no association between common variants in the estrogen receptor alpha and epidermal growth factor genes and breast cancer risk, tumour characteristics or survival.
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1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) disrupts the estrogen-androgen balance regulating the growth of hormone-dependent breast cancer cells
Michel Aubé, Christian Larochelle, Pierre Ayotte Breast Cancer Research 2008, 10:R16 (14 February 2008)
Abstract | Full text | PDF | PubMed | F1000 Biology
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Editor’s summary
The main metabolite of the insecticide, DDT could increase breast cancer progression by a mechanism whereby the metabolite opposes the androgen signalling pathway that inhibits growth in hormone-responsive breast cancer cells.
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Basal cytokeratins in breast tumours among BRCA1, BRCA2 and mutation-negative breast cancer families
Hannaleena Eerola, Mira Heinonen, Päivi Heikkilä, Outi Kilpivaara, Anitta Tamminen, Kristiina Aittomäki, Carl Blomqvist, Ari Ristimäki, Heli Nevanlinna Breast Cancer Research 2008, 10:R17 (14 February 2008)
Abstract | Full text | PDF | PubMed
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Chemopreventive effects of celecoxib are limited to hormonally responsive mammary carcinomas in the neu-induced retroviral rat model
Stephan Woditschka, Jill D Haag, Bob Mau, Ronald A Lubet, Michael N Gould Breast Cancer Research 2008, 10:R18 (15 February 2008)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Dietary celecoxib had no significant effect on hormonally non-responsive mammary carcinoma in a rat model, questioning its suitability for prevention of this form of breast cancer and its use in combination therapy.
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Evaluation of unclassified variants in the breast cancer susceptibility genes BRCA1 and BRCA2 using five methods: results from a population-based study of young breast cancer patients
Eunjung Lee, Roberta McKean-Cowdin, Huiyan Ma, Zhengjia Chen, David Van Den Berg, Brian E Henderson, Leslie Bernstein, Giske Ursin Breast Cancer Research 2008, 10:R19 (19 February 2008)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Five methods used to evaluate unclassified variants (UVs) in breast cancer susceptibility genes had high correlation, suggesting their application may be useful for evaluating UVs when little functional or clinical data are available.
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Breast cancer subtypes and survival in patients with brain metastases
Byung-Ho Nam, Sun Kim, Hye-Sook Han, Youngmee Kwon, Keun Lee, Tae Kim, Jungsil Ro Breast Cancer Research 2008, 10:R20 (28 February 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Patients with three breast cancer subtypes have a higher risk of developing brain metastases, suggesting that screening the receptor status of tumors could help predict the likely survival of patients.
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Forkhead box transcription factor FOXO3a suppresses estrogen-dependent breast cancer cell proliferation and tumorigenesis
Yiyu Zou, Wen-Bin Tsai, Chien-Jui Cheng, Chiun Hsu, Young Chung, Pao-Chen Li, Sue-Hwa Lin, Mickey CT Hu Breast Cancer Research 2008, 10:R21 (29 February 2008)
Abstract | Full text | PDF | PubMed
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