Additional file 7.
File showing the sensitivity of Brca1 cell lines to doxorubicin, cisplatin, and the HSP90 inhibitor 17-DMAG. Cytotoxicity is determined by MTS assay for four representative Brca1 cell lines: A1.8, P3.17, B.15, and RP.1. Cells were exposed to increasing concentrations of (A) doxorubicin, (B) cisplatin, and (C) the HSP90 inhibitor 17-DMAG. Percentage survival (± standard deviation from six replicate wells) after 24 hours of exposure to drugs is represented by open symbols and dotted lines, and after 48 hours by solid symbols and lines. The ordinate shows concentrations of individual drugs. One of three independent experiments for each cell type is shown here.
Format: PPT Size: 119KB Download file
This file can be viewed with: Microsoft PowerPoint Viewer
Wright et al. Breast Cancer Research 2008 10:R10 doi:10.1186/bcr1855