Figure 7.

Multivariate analysis of dichotomised HER2 FISH with continuous HER1, HER3 or HER4 FISH. Individually calculated hazard ratios (overall survival, HRind = EXP [B_HER2 × HER2 dichotomised + B_HERx × HERx continuous]) for HER1 (a), HER3 (b) and HER4 (c) fluorescence in situ hybridisation, divided into HER2 amplified (ratio ≥ 1.6; filled circles) and HER2 non-amplified (ratio ≤ 1.5; open circles) patients.