Table 3

Cox proportional hazards analysis for overall and disease-free survival
Technique
 Parameter
 Overall survival
 Disease-free survival


HR
 95% CI
 p
 HR
 95% CI
 p
FISH
 HER1






     Continuous 0.1
 1.02
 0.97–1.07
 0.380
 1.03
 0.98–1.07
 0.301

     Continuous 1.0
 1.24
 0.77–2.00
1.28
 0.80–2.03

HER2






     Continuous 0.1
 1.02
 1.01–1.02
 0.001
 1.02
 1.01–1.03
 <0.001

     Continuous 1.0
 1.16
 1.06–1.26
1.18
 1.08–1.29

     Dichotomous (≤1.5 vs. ≥1.6)
 2.07
 1.33–3.21
 0.001
 2.33
 1.48–3.68
 <0.001

HER3






     Continuous 0.1
 1.07
 0.99–1.15
1.09
 1.01–1.18
 0.031

     Continuous 1.0
 1.88
 0.88–4.01
 0.102
 2.35
 1.08–5.11

HER4






     Continuous 0.1
 0.90
 0.75–1.09
 0.289
 0.92
 0.76–1.12
 0.395

     Continuous 1.0
 0.36
 0.06–2.36
0.43
 0.06–3.03
IHC
 HER1
 1.66
 0.96–2.86
 0.070
 1.55
 0.87–2.77
 0.139

HER2
 1.42
 0.90–2.25
 0.131
 1.58
 0.99–2.54
 0.057

HER3
 0.84
 0.51–1.37
 0.484
 0.93
 0.55–1.56
 0.778

HER4
 1.48
 0.97–2.26
 0.070
 1.51
 0.97–2.33
 0.066

HER2 divided
 1.72
 1.07–2.75
 0.024
 1.89
 1.16–3.08
 0.010

Ki-67
 1.49
 0.87–2.55
 0.145
 1.44
 0.83–2.49
 0.197

ER
 0.58
 0.37–0.91
 0.018
 0.59
 0.37–0.96
 0.031

PR
 0.48
 0.27–0.74
 0.002
 0.42
 0.24–0.71
 0.001
Histology
 pT
 1.62
 1.35–1.93
 <0.001
 1.72
 1.43–2.08
 <0.001

pN
 1.98
 1.67–2.35
 <0.001
 2.18
 1.81–2.62
 <0.001

Grading
 2.10
 1.54–2.87
 <0.001
 2.18
 1.56–3.05
 <0.001

Hazard ratios (HR), confidence intervals and p values of investigated parameters dependent on overall and disease-free survival (CI, confidence interval with lower and upper limits). All immunohistochemical and histological parameters were used as categorical variables. FISH, fluorescence in situ hybridisation; IHC, immunohistochemistry.

Sassen et al. Breast Cancer Research 2008 10:R2   doi:10.1186/bcr1843

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