Table 1

Comparison of the effect of ibandronate on six breast cancer cell lines

IC₅₀ (μmol/l)

Cell line

ER status^a

Bone lesions^b

0.6 mmol/l calcium

1.6 mmol/l calcium

T-47D

+

Blastic

35^c

2

ZR-75-1

+

Lytic

50

15

MCF-7

+

Blastic

80

10

Hs-578T

-

Blastic

100

10

BT-549

-

Lytic

150

10

MDA-MB-231

-

Lytic

150

60

^aAs described by American Type Culture Collection (Manassas, VA, USA). ^bAs defined by Yin and coworkers [32] and Lacroix and colleagues [33]. ^cHalf maximal inhibitory concentration (IC₅₀) values determined from concentration-effect curves for cancer cells exposed for 72 hours to ibandronate (1 to 1,000 μmol/l) in the presence of 0.6 or 1.6 mmol/l calcium. Cell culture densities were evaluated by crystal violet staining assay. Means of results pooled from three experiments (n = 18). ER, oestrogen receptor.

Journé et al. Breast Cancer Research 2008 10:R4   doi:10.1186/bcr1845