Table 1

Kappa values


One cell
≥ 10% invasive tumour staining
≥ 20% invasive tumour staining



Obs. 1
Obs. 2
Obs. 1
Obs. 2
Obs. 1
Obs. 2

TMA biopsy versus whole section (central)
0.56
0.51
0.71
0.65
0.68
0.61
TMA biopsy versus whole section (peripheral)
0.52
0.37
0.59
0.59
0.59
0.58
Two different paraffin blocks (central biopsies)
0.72
0.56
0.69
0.86
0.89
0.86
Two different paraffin blocks (peripheral biopsies)
0.66
0.33
0.42
0.49
0.41
-0.07
Whole sections (two different paraffin blocks)
0.70
0.55
0.72
0.74
0.70
0.70

Presented are κ values that describe comparisons between immunohistochemial stainings for carbonic anhydrase IX of 108 tissue microarray biopsies and 54 whole sections from 27 breast carcinomas. The κ values are presented for two observers and using different cut-points for determining positivity.

Kyndi et al. Breast Cancer Research 2008 10:R24   doi:10.1186/bcr1981