Table 3

Odds ratios for postmenopausal breast cancer by polymorphisms in the vitamin D receptor gene
Genotype
 Cases
 Controls
 Crude modela
 Adjusted modelb

n
 %
 n
 %
 OR (95% CI)
OR (95% CI)
Pc
TaqI
 1,403
2,609




0.33
     TT
 497
 35.4
 980
 37.6
 1
1

     Tt
 667
 47.6
 1,218
 46.7
 1.08
 (0.94–1.25)
 1.08
 (0.93–1.26)
     tt
 239
 17.0
 411
 15.7
 1.15
 (0.95–1.39)
 1.11
 (0.91–1.36)
     Tt/tt



1.10
 (0.96–1.26)
 1.09
 (0.95–1.26)
FokI
 1,390
2,596




0.24
     FF
 566
 40.7
 998
 38.5
 1
1

     Ff
 606
 43.6
 1,203
 46.3
 0.88
 (0.77–1.02)
 0.89
 (0.77–1.03)
     ff
 218
 15.7
 395
 15.2
 0.98
 (0.80–1.19)
 0.97
 (0.79–1.19)
     Ff/ff



0.91
 (0.80–1.04)
 0.91
 (0.79–1.05)
VDR-5132
 1,400
2,607




0.92
     CC
 488
 34.9
 892
 34.2
 1
1

     CT
 683
 48.8
 1,284
 49.3
 0.99
 (0.85–1.14)
 1.00
 (0.86–1.16)
     TT
 229
 16.3
 431
 16.5
 0.99
 (0.81–1.20)
 1.01
 (0.83–1.24)
     CT/TT



0.99
 (0.86–1.13)
 1.00
 (0.87–1.16)
Cdx2
 1,406
2,606




0.22
     GG
 888
 63.1
 1,701
 65.3
 1
1

     GA
 465
 33.1
 795
 30.5
 1.11
 (0.97–1.28)
 1.08
 (0.94–1.25)
     AA
 53
 3.8
 110
 4.2
 0.94
 (0.67–1.32)
 0.94
 (0.66–1.33)
     GA/AA



1.09
 (0.95–1.25)
 1.07
 (0.93–1.23)

aConditional logistic regression stratified by year of birth. bConditional logistic regression stratified by year of birth adjusted for age at menopause, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies (≥28th week), age at menarche, breastfeeding history, total number of mammograms, use of hormone therapy, body mass index, education level and smoking status. cχ2 test for difference between cases and controls comparing the three genotypes for each polymorphism. CI, confidence interval; OR, odds ratio.

Abbas et al. Breast Cancer Research 2008 10:R31   doi:10.1186/bcr1994