Table 5 |
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|
Odds ratios for postmenopausal breast cancer by haplotypes in the vitamin D receptorgene under the log-additive model |
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|
Haplotypea |
Haplotype frequencies (%) |
OR (95% CI) |
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|
|
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|
Cases (n = 1,408) |
Controls (n = 2,612) |
Crude modelb |
Adjusted modelc |
|||
|
|
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|
FTCG |
0.178 |
0.183 |
1 |
1 |
||
|
FTCA |
0.036 |
0.049 |
0.76 |
(0.51–1.15) |
0.81 |
(0.53–1.23) |
|
FTTG |
0.124 |
0.116 |
1.12 |
(0.87–1.43) |
1.09 |
(0.84–1.40) |
|
FTTA |
0.025 |
0.025 |
1.10 |
(0.69–1.77) |
1.16 |
(0.71–1.88) |
|
FtCG |
0.117 |
0.113 |
1.07 |
(0.83–1.38) |
1.06 |
(0.82–1.39) |
|
FtCA |
0.052 |
0.035 |
1.50 |
(1.07–2.12) |
1.43 |
(1.00–2.05) |
|
FtTG |
0.076 |
0.079 |
0.98 |
(0.76–1.27) |
1.04 |
(0.80–1.36) |
|
FtTA |
0.016 |
0.015 |
1.05 |
(0.59–1.87) |
0.98 |
(0.54–1.79) |
|
fTCG |
0.109 |
0.117 |
0.97 |
(0.75–1.24) |
0.97 |
(0.75–1.26) |
|
fTCA |
0.028 |
0.023 |
1.19 |
(0.72–1.96) |
1.17 |
(0.70–1.95) |
|
fTTG |
0.080 |
0.083 |
0.98 |
(0.75–1.26) |
1.04 |
(0.80–1.35) |
|
fTTA |
0.011 |
0.011 |
1.07 |
(0.48–2.37) |
0.93 |
(0.41–2.09) |
|
ftCG |
0.048 |
0.041 |
1.19 |
(0.84–1.69) |
1.19 |
(0.82–1.72) |
|
ftCA |
0.024 |
0.027 |
0.94 |
(0.57–1.55) |
0.95 |
(0.56–1.64) |
|
ftTG |
0.065 |
0.072 |
0.94 |
(0.71–1.25) |
0.94 |
(0.70–1.27) |
|
|
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|
aFokI, TaqI, VDR-5132, Cdx2 (with > 1% frequency in the study population). bUnconditional haplotype analysis adjusted for matching factor year of birth. cUnconditional haplotype analysis adjusted for year of birth, age at menopause, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies (≥28th week), age at menarche, breastfeeding history, total number of mammograms, use of hormone therapy, body mass index, education level and smoking status. CI, confidence interval; OR, odds ratio. |
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|
Abbas et al. Breast Cancer Research 2008 10:R31 doi:10.1186/bcr1994 |
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