Table 3 |
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|
Association between phytoestrogen biomarkers and breast cancer risk in the European Prospective into Cancer-Norfolk study |
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|
Serum (ng/ml) |
Urine (μg/mmol creatinine) |
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|
|
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|
Odds ratio |
95% confidence interval |
P value |
Odds ratio |
95% confidence interval |
P value |
|
|
|
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|
Full study |
(219 cases/891 controls) |
(198 cases/797 controls) |
||||
|
Total isoflavones |
1.03 |
0.95 to 1.11 |
0.479 |
1.08 |
1.00 to 1.16 |
0.055 |
|
Total lignans |
0.99 |
0.90 to 1.08 |
0.728 |
1.01 |
0.94 to 1.09 |
0.758 |
|
Daidzein |
1.04 |
0.98 to 1.10 |
0.225 |
1.05 |
0.99 to 1.10 |
0.096 |
|
Equol |
1.04 |
0.98 to 1.10 |
0.167 |
1.03 |
0.99 to 1.06 |
0.131 |
|
o-Desmethylangolensin |
1.03 |
0.97 to 1.09 |
0.390 |
1.02 |
0.98 to 1.06 |
0.250 |
|
Genistein |
1.00 |
0.94 to 1.05 |
0.911 |
1.01 |
0.97 to 1.05 |
0.706 |
|
Glycitein |
1.03 |
0.97 to 1.10 |
0.345 |
1.03 |
0.98 to 1.07 |
0.248 |
|
Enterodiol |
1.02 |
0.96 to 1.09 |
0.461 |
1.01 |
0.96 to 1.05 |
0.772 |
|
Enterolactone |
0.98 |
0.91 to 1.05 |
0.564 |
0.99 |
0.94 to 1.04 |
0.718 |
|
Oestrogen receptor-positive subgroup |
(105 cases/365 controls) |
(95 cases/329 controls) |
||||
|
Total isoflavones |
1.01 |
0.91 to 1.12 |
0.818 |
1.09 |
0.97 to 1.22 |
0.154 |
|
Total lignans |
1.02 |
0.89 to 1.17 |
0.774 |
1.12 |
0.99 to 1.28 |
0.083 |
|
Daidzein |
1.05 |
0.97 to 1.13 |
0.260 |
1.03 |
0.96 to 1.10 |
0.468 |
|
Equol |
1.01 |
0.93 to 1.09 |
0.887 |
1.07 |
1.01 to 1.12 |
0.013 |
|
o-Desmethylangolensin |
1.05 |
0.96 to 1.14 |
0.314 |
1.04 |
0.98 to 1.10 |
0.192 |
|
Genistein |
0.99 |
0.92 to 1.06 |
0.775 |
1.00 |
0.94 to 1.05 |
0.882 |
|
Glycitein |
1.03 |
0.93 to 1.13 |
0.614 |
1.04 |
0.98 to 1.10 |
0.186 |
|
Enterodiol |
1.00 |
0.92 to 1.09 |
0.990 |
1.04 |
0.98 to 1.11 |
0.235 |
|
Enterolactone |
1.01 |
0.91 to 1.14 |
0.806 |
1.08 |
0.98 to 1.19 |
0.115 |
|
|
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|
Values are log2-transformed and adjusted for weight, oral contraceptive use, menopausal hormone treatment, menopausal status, parity, menarche, breastfeeding, family history of breast cancer, daily intake of fat and energy, and batch. |
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|
Ward et al. Breast Cancer Research 2008 10:R32 doi:10.1186/bcr1995 |
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