Figure 1.

Distribution of P values computed from the unequal variance t test in patients with estrogen receptor (ER)-negative and ER-positive tumors. (a) Gene expressions were compared between ER-negative tumors that had pathologic complete response and those that had a lesser response to preoperative chemotherapy. The resulting P values for all comparisons were modeled as beta-uniform mixture. The straight line indicates the contribution of the uniform component, and the curved line is the fitted beta-distribution from the observed values. Deviation above the straight line indicates P values that may represent true discovery. (b) Distribution of P values in patients with ER-positive tumors.