|
Association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer among 126,124 women, National Institutes of Health–AARP Study |
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| Number of cancers |
Person-years |
Relative riska |
95% confidence interval |
P value for trend |
|
|
|
|||||
| NSAID use |
|||||
| Never |
667 |
124,265 |
1.00 (referent) |
n/a |
|
| Aspirin only |
1,085 |
203,145 |
0.97 |
0.88 to 1.07 |
|
| Non-aspirin NSAID only |
874 |
157,017 |
1.01 |
0.92 to 1.12 |
|
| Both |
1,781 |
334,792 |
0.95 |
0.87 to 1.04 |
|
| Aspirin useb |
|||||
| Never |
1,556 |
284,342 |
1.00 (referent) |
0.08 |
|
| <1/week |
1,405 |
265,676 |
0.95 |
0.89 to 1.03 |
|
| 1–6/week |
716 |
133,331 |
0.95 |
0.87 to 1.04 |
|
| 1+/day |
774 |
145,317 |
0.93 |
0.85 to 1.01 |
|
| Non-aspirin NSAID useb |
|||||
| Never |
1,764 |
329,944 |
1.00 (referent) |
0.58 |
|
| <1/week |
1,415 |
262,000 |
1.00 |
0.93 to 1.07 |
|
| 1–6/week |
693 |
126,373 |
1.02 |
0.93 to 1.11 |
|
| 1+/day |
585 |
109,098 |
0.96 |
0.87 to 1.05 |
|
|
aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative. bThese models also include terms for frequency of use of opposite NSAID type. | |||||
Gierach et al. Breast Cancer Research 2008 10:R38 doi:10.1186/bcr2089 |
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