Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
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* Corresponding author: John L Hopper j.hopper@unimelb.edu.au
1 Epidemiology Methods and Support Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France
2 Department of Pathology, The University of Melbourne, Victoria 3010, Australia
3 Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Swanston Street, Carlton, Victoria 3053, Australia
Breast Cancer Research 2008, 10:208 doi:10.1186/bcr2099
Published: 5 June 2008Additional files
Additional file 1:
Additional file 1 is a Word document containing calculations, based on a logistic model for lifetime risk of breast cancer, of the FRR resulting from a given number of alleles of specified per-allele odds-ratio and allele frequency. It also contains calculations of the number of SNPs required to produce a typical FRR.
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