Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?

doi:10.1186/bcr2099

Breast Cancer Research

Volume 10
Issue 3

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Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?

Graham B Byrnes¹ , Melissa C Southey² and John L Hopper³

¹Epidemiology Methods and Support Group, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon, France

²Department of Pathology, The University of Melbourne, Victoria 3010, Australia

³Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Swanston Street, Carlton, Victoria 3053, Australia

author email corresponding author email

Breast Cancer Research 2008, 10:208doi:10.1186/bcr2099


Published:	5 June 2008

Additional files

Additional file 1:

Additional file 1 is a Word document containing calculations, based on a logistic model for lifetime risk of breast cancer, of the FRR resulting from a given number of alleles of specified per-allele odds-ratio and allele frequency. It also contains calculations of the number of SNPs required to produce a typical FRR.

Format: DOC Size: 32KB Download file

This file can be viewed with: Microsoft Word Viewer