The future of mammary stem cell biology: the power of in vivo transplants – authors' response

doi:10.1186/bcr1993

Breast Cancer Research

Volume 10
Issue 3

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Letter

The future of mammary stem cell biology: the power of in vivo transplants – authors' response

Gilbert H Smith¹ and Daniel Medina²

¹Mammary Stem Cell Biology Section, Mammary Biology and Tumorigenesis Laboratory, CCR, NCI, Convent Drive, National Institutes of Health, Bethesda, Maryland 20892, USA

²Department of Molecular and Cellular Biology, Baylor College of Medicine, Baylor Plaza, Houston, Texas 77030, USA

author email corresponding author email

Breast Cancer Research 2008, 10:403doi:10.1186/bcr1993


Published:	29 May 2008

See related letter by Lindeman et al., http://breast-cancer-research.com/content/10/3/402 and related review article by Smith and Medina, http://breast-cancer-research.com/content/10/1/203

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The letter from Lindeman and coworkers [1] conveys their concern regarding the future of prospective isolation and characterization of individual cells that may be characterized as mammary stem cells upon in vivo transplantation. As they have pointed out, the difficulties encountered in identifying specific mammary epithelial subtypes by different levels of fluorescence (particularly for membrane components that decorate most if not all mammary epithelial cells) leads to differential reporting and 'resultant confusion' and 'underscores the need for improved standardization'.