Table 2 |
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|
Means and correlations of IGFBP-3 levels with IGF-I levels and women's characteristics |
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| Adjusted means of IGFBP-3 levelsa |
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|
|
||||
| Number |
Intact, ng/mL |
Fragmented, ng/mL |
Total, ng/mL |
|
|
|
||||
| Total IGF-I, ng/mL |
||||
| ≤179.6 |
185 |
1,051 |
3,081 |
4,132 |
| 179.7–218.1 |
184 |
1,040 |
3,587 |
4,627 |
| 218.2–260.7 |
184 |
1,033 |
3,935 |
4,968 |
| > 260.7 |
184 |
1,051 |
4,451 |
5,502 |
| rb (P) |
0.010 (0.78) |
0.554 (< 0.0001) |
0.555 (< 0.0001) |
|
| rb (P)a |
0.023 (0.53) |
0.588 (< 0.0001) |
0.588 (< 0.0001) |
|
| Age at mammography, years |
||||
| ≤44 |
221 |
1,007 |
3,673 |
4,680 |
| 45–47 |
168 |
1,025 |
3,746 |
4,770 |
| 48–50 |
200 |
1,062 |
3,821 |
4,883 |
| > 50 |
148 |
1,096 |
3,835 |
4,931 |
| rb (P) |
0.083 (0.02) |
0.028 (0.46) |
0.049 (0.19) |
|
| rb (P)a |
0.113 (0.002) |
0.104 (0.005) |
0.139 (0.0002) |
|
| Body mass index, kg/m2 |
||||
| ≤22.0 |
186 |
1,071 |
3,680 |
4,750 |
| 22.1–24.4 |
187 |
1,057 |
3,671 |
4,728 |
| 24.5–27.4 |
183 |
1,003 |
3,771 |
4,775 |
| > 27.4 |
181 |
1,044 |
3,932 |
4,976 |
| rb (P) |
-0.070 (0.06) |
0.153 (< 0.0001) |
0.134 (0.0003) |
|
| rb (P)a |
-0.024 (0.52) |
0.124 (0.0008) |
0.115 (0.002) |
|
| Waist-to-hip ratio |
||||
| ≤0.740 |
184 |
1,106 |
3,620 |
4,726 |
| 0.741–0.780 |
196 |
1,062 |
3,708 |
4,770 |
| 0.781–0.820 |
185 |
987 |
3,685 |
4,671 |
| > 0.820 |
172 |
1,017 |
4,061 |
5,078 |
| rb (P) |
-0.139 (0.0001) |
0.188 (< 0.0001) |
0.152 (< 0.0001) |
|
| rb (P)a |
-0.128 (0.0005) |
0.156 (< 0.0001) |
0.115 (0.002) |
|
| Alcohol intake, drinks/week |
||||
| Non-drinkers |
53 |
1,080 |
3,691 |
4,771 |
| ≤1.0 |
234 |
1,066 |
3,716 |
4,781 |
| 1.1–4.0 |
238 |
1,063 |
3,734 |
4,797 |
| > 4.0 |
212 |
989 |
3,864 |
4,853 |
| rb (P) |
-0.113 (0.002) |
0.002 (0.96) |
-0.027 (0.46) |
|
| rb (P)a |
-0.137 (0.0002) |
0.079 (0.03) |
0.035 (0.34) |
|
| Energy intake, kilocalories/day |
||||
| ≤1,564.21 |
185 |
1,023 |
3,807 |
4,830 |
| 1,564.22–1,855.02 |
184 |
1,040 |
3,837 |
4,878 |
| 1,855.03–2,199.36 |
184 |
1,031 |
3,756 |
4,787 |
| > 2,199.36 |
184 |
1,081 |
3,649 |
4,730 |
| rb (P) |
0.058 (0.12) |
-0.004 (0.92) |
0.011 (0.76) |
|
| rb (P)a |
0.075 (0.04) |
-0.080 (0.03) |
-0.055 (0.14) |
|
| Physical activity, MET-hours/week |
||||
| ≤10.79 |
185 |
1,036 |
3,647 |
4,683 |
| 10.80–22.27 |
184 |
1,052 |
3,737 |
4,789 |
| 22.28–36.64 |
184 |
1,033 |
3,783 |
4,815 |
| > 36.64 |
184 |
1,055 |
3,884 |
4,939 |
| rb (P) |
0. 077 (0.04) |
0.031 (0.40) |
0.050 (0.17) |
|
| rb (P)a |
0.069 (0.06) |
0.097 (0.009) |
0.118 (0.002) |
|
| Parity |
||||
| Nulliparous |
178 |
1,079 |
3,616 |
4,695 |
| Parous |
559 |
1,033 |
3,809 |
4,842 |
| rs c (P) |
-0.063 (0.09) |
0.135 (0.0002) |
0.121 (0.001) |
|
| rs c (P)a |
-0.078 (0.04) |
0.110 (0.003) |
0.089 (0.02) |
|
| Smoking status |
||||
| None/ex-smoker |
627 |
1,048 |
3,791 |
4,839 |
| Current |
110 |
1,020 |
3,598 |
4,618 |
| rs c (P) |
-0.094 (0.01) |
-0.117 (0.001) |
-0.129 (0.0004) |
|
| rs c (P)a |
-0.063 (0.09) |
-0.090 (0.01) |
-0.091 (0.01) |
|
|
|
||||
|
aMeans and correlations are adjusted for variables in the table. bPearson correlation (r) between continuous variables; adjusted correlations are partial Pearson coefficients. cSpearman correlation (rs) between dichotomous factor and continuous levels of IGFBP-3; adjusted correlations are partial Spearman coefficients. IGF, insulin-like growth factor; IGFBP-3, insulin-like growth factor-binding protein-3; MET, metabolic equivalent. |
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|
Diorio et al. Breast Cancer Research 2008 10:R42 doi:10.1186/bcr2093 |
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