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Means and correlations of IGFBP-3 levels with mammographic breast density |
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| Adjusted means of percent density (percentage)a |
Adjusted means of absolute density (cm2)a,b |
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| Levels of IGFBP-3 |
Intactc |
Fragmentedd |
Totale |
Intactc |
Fragmentedd |
Totale |
| Quartile 1 (n = 185) |
42.2 |
45.3 |
44.5 |
48.6 |
48.3 |
49.4 |
| Quartile 2 (n = 184) |
42.9 |
44.3 |
44.7 |
46.3 |
48.0 |
48.6 |
| Quartile 3 (n = 184) |
40.4 |
40.3 |
40.7 |
45.7 |
45.9 |
45.0 |
| Quartile 4 (n = 184) |
44.0 |
39.6 |
39.6 |
45.5 |
43.9 |
43.1 |
| rf (P) |
0.075 (0.04) |
-0.171 (< 0.0001) |
-0.151 (< 0.0001) |
-0.010 (0.79) |
-0.092 (0.01) |
-0.094 (0.01) |
| rf (P)a |
0.031 (0.40) |
-0.105 (0.004) |
-0.095 (0.01) |
-0.029 (0.43) |
-0.066 (0.07) |
-0.075 (0.04) |
| rf (P)g |
0.022 (0.55) |
-0.112 (0.003) |
-0.104 (0.005) |
-0.042 (0.26) |
-0.078 (0.04) |
-0.090 (0.02) |
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aMeans and correlations are adjusted for age, body mass index, waist-to-hip ratio, alcohol intake, energy intake, physical activity, parity, smoking status, and total IGF-I levels. bMeans of absolute density are presented as back-transformed values; square-root-transformed absolute density is used in the correlation. cQuartiles of intact IGFBP-3 are ≤883.80, 883.81 to 1,021.00, 1,021.01 to 1,170.50, and > 1,170.50 ng/mL. dQuartiles of fragmented IGFBP-3 are ≤3,137.50, 3,137.51 to 3,662.50, 3,662.51 to 4,263.00, and > 4,263.00 ng/mL. eQuartiles of total IGFBP-3 are ≤4,183.0, 4,183.1 to 4,695.0, 4,695.1 to 5,290.0, and > 5,290.0 ng/mL. fPearson correlation between continuous variables; adjusted correlations are partial Pearson coefficients. gCorrelations are adjusted for age, body mass index, waist-to-hip ratio, alcohol intake, energy intake, physical activity, parity, smoking status, total IGF-I levels, age at menarche, number of full-term pregnancies, age at first full-term pregnancy, lactation, family history of breast cancer, number of breast biopsies, education, past use of oral contraceptives, past use of hormone replacement therapy, and height. | ||||||
Diorio et al. Breast Cancer Research 2008 10:R42 doi:10.1186/bcr2093 |
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