Additional file 1.

A tif file summarizing CGH and microsatellite analysis by line. For each line, samples of MINO and the matched tumor were analyzed by BAC array CGH and multiplexed PCR for microsatellite changes. For CGH results, changes that were seen in all of the MINO or tumor samples from each line are depicted in solid color, and changes seen in less than 100% of samples in cross-hatched color with the fraction and total number given below. Whole chromosome gains (WCGs) are shown as rectangular boxes, whereas smaller amplifications are depicted as ovals with (+) symbols and deletions as ovals with (-) symbols. The approximate relative chromosomal location is mapped with the chromosomes depicted along the left edge. The microsatellites are depicted as small boxes, with two at each position depicting the two alleles. Empty squares are microsatellites matching the normal control sample (wild-type FVB/n) and filled squares are changes in microsatellite length from normal. In most cases, the length change was seen in one of the two alleles, but in a few areas both alleles were altered as in MINO line 8wD at centromeric chromosome 2 (top of chromosome 2 as depicted) where both squares are filled. **Line 4w6 was not studied by microsatellite analysis.

Format: TIFF Size: 469KB Download file

Damonte et al. Breast Cancer Research 2008 10:R50   doi:10.1186/bcr2104