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Table 1
Summary of CGH BAC array and multiplexed microsatellite PCR length changes in the MINO precancer tissue and paired invasive carcinoma
Line designation/G0 generation #		Generation G0		Generation G0+1

		MINO	Paired tumor	MINO	Paired tumor

Line A	CGH whole chromosome	+ch13WC	Same	→ Same	→ Same +ch11WC
G0 = 12th	CGH locus changes	+ch5BAC1	Same	→ Same +ch5BAC2	→ Same
	MS			d5–95; d7–253	→ Same +d6–123; d9–90
(Replicate animal)	CGH whole chromosome			Same	Same +ch11WC
	CGH locus changes			Normal	Normal
Line D	CGH	Normal	Normal
G0 = 12th	MS	d1–24; d2–149; d4–178; d12–109; d12–182; d14–170	→ Same less d1–24; plus d7–165
Line 11	CGH whole chromosome	Normal	Normal
G0 = 11th	CGH locus changes	Normal	+ch5distalG1:G3 (17 BACs); +ch11BACs3–5
	MS	d2–149; d4–166; d5–113; d8–205; d11–61; d16–131; d18–19	→ Same less d2–149; plus d9–182
Line B	CGH	+ch1WC, +ch2WC, +10WC, +11WC,	→ Same less +ch11WC, plus +ch15WC
G0 = 14th		+ch3BAC6, +ch17BAC7	→ Same plus +ch5BAC1, +ch5BAC2, del ch7BAC8, del ch8BAC9, del ch10BAC10
	MS	d6–138, d8–93, d8–120, d10–14, d11–61	→ Same +d17–93
Line 4	CGH whole chromosomes	+ch1WC	+ch2WC	+ch2WC	→ Same
G0 = 13th	CGH locus changes	+ch5BAC1, +ch6BAC11	→ Same less ch6BAC11	Normal	del-ch2BAC12, del-ch6BACBAC13, del-ch18BAC14, del-ch18BAC15
	MS			d1–102, d2–149, d12–109, d12–182, d12-nds, d15–175, d3–57	→ Same less d2–149
Line 6	CGH whole chromosome	Normal	Normal	+ch1WC	→ Same
G0 = 11th	CGH locus changes	Normal	Normal	+distal ch5G1:G3 (18 BACs), +ch3BAC2	→ Same
(Replicate animal)	CGH whole chromosome	Normal	Normal
	CGH locus changes	Normal	Normal

The initial serial transplant generation (G0) tested is given for each line, and, for several lines, a successive generation (G0+1) was tested. Replicate animals transplanted at the same time from the same donor (previous generation) were also tested. The changes from normal are listed as comparative genomic hybridization (CGH) detected whole chromosome (WC) gains (+ch#), CGH focal locus amplifications (+) and deletions (del). The bacterial artificial chromosome (BAC) clones are numbered as follows: BAC1 = RP23 422O10; BAC2 = RP23 93M18; BAC3 = RP23 276J22; BAC4 = RP23 295O13; BAC5 = P1–7858; BAC6 = RP23 233B21; BAC7 = RP23 193I17; BAC8 = RP23 413L18; BAC9 = RP23 23D17; BAC10 = RP23 421E11; BAC11 = RP23 127M17; BAC12 = RP23 129L11; BAC13 = RP23 393H9; BAC14 = RP23 27B11; and BAC15 = RP23 35M16. Most of the BACs are from Roswell Park (RP) 23 collection. Also shown are microsatellite (MS) changes compared with normal control (MSs were not tested for line 6). Specifics of MS changes are available in Additional file 2. The arrows indicate comparisons with samples either from a previous generation or from the MINO preceding the invasive cancer (→) or from a different transplant in the same generation listed in rows above (). MINO, mammary intraepithelial neoplasia outgrowth.
Damonte et al. Breast Cancer Research 2008 10:R50 doi:10.1186/bcr2104

Table 1