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Tumorigenicity of cells from pleural effusion mammospheres |
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| Sample |
Average size of mammospheres (μm) |
Percentage of CD44+/CD24low/- cells |
Tumorigenicity |
|
|
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| PE88 |
20 |
37 |
0/3a |
| PE62 |
20 |
13.2 |
0/3 |
| PE6 |
30 |
1.5 |
0/3 |
| PE43 |
50 |
9.9 |
0/3 |
| 06PE8 |
70 |
70.6 |
4/7 |
| 06PE6 |
100 |
15.3 |
1/3 |
| PE14 |
100 |
All cells CD24- and CD44- |
5/7 |
| PE66 |
130 |
6.8 |
1/3 |
|
Mice were injected with 5,000 cells from disrupted mammospheres as described in Materials and methods. aThe ratio of mice developing tumours over mice injected. PE, pleural effusion. | |||
Grimshaw et al. Breast Cancer Research 2008 10:R52 doi:10.1186/bcr2106 |
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