Breast Cancer Research

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Breast cancer stem cells: implications for therapy of breast cancer

Brian J Morrison, Chris W Schmidt, Sunil R Lakhani, Brent A Reynolds and J Alejandro Lopez*

Breast Cancer Research 2008, 10:210 doi:10.1186/bcr2111

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Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype

Kevin Roarty, Sarah E Baxley, Michael R Crowley, Andra R Frost, Rosa Serra Breast Cancer Research 2009, 11:R19 (3 April 2009)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central | Editor’s summary

Loss of TGF-ß or Wnt5a, proteins involved in Wnt/ß-catenin regulation, can redirect the phenotype of mammary tumours to resemble those induced by excessive Wnt/ß-catenin, suggesting a new tumour suppressive mechanism.

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