Molecular targeted therapies for breast cancer treatment

doi:10.1186/bcr2112

Breast Cancer Research

Volume 10
Issue 4

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Vogt U
Allgayer H
Brandt B

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Allgayer H
Brandt B
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Molecular targeted therapies for breast cancer treatment

Claus M Schlotter¹, Ulf Vogt², Heike Allgayer³ and Burkhard Brandt⁴

¹Department of Obstetrics and Gynecology, Breast Centre Klinikum Lüdenscheid, Academic Teaching Hospital of the University Bonn, Luedenscheid, Paulmannshoeher Str. 14 – 58515 Luedenscheid Germany

²European Laboratory Association, Ibbenbueren, Roggenkampstr. 12 49477 Ibbenbueren Germany

³Department of Experimental Surgery and Molecular Oncology, Faculty Mannheim, University Heidelberg, Molecular of Solid Tumors, German Cancer Research Center (DKFZ), Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim Germany

⁴Institute for Tumor Biology, University Medical Center Hamburg-Eppendorf, Campus Forschung N 27 Martinistraße 52, 20246 Hamburg, Germany

author email corresponding author email

Breast Cancer Research 2008, 10:211doi:10.1186/bcr2112


Published:	24 July 2008

Abstract

Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy. New targeted therapeutic approaches to induction of apoptosis or inhibition of anti-apoptosis, cell cycle progression, signal transduction and angiogenesis are described. The molecular pathways and their inhibitory or repair mechanisms are discussed in the preclinical and clinical settings.