Table 1

Biological roles of insulin-like growth factor binding protein 5 (IGFBP-5) in different types of cancer

Cancer type

Source of tissue or cell line

Application of the study or study design

Observed functional effects of IGFBP-5

Ref.

Breast

T47D

Intracellular trafficking

Nuclear localization of IGFBP-5

[31]

Hs578T

Analysis of mitogenic effect of IGFBP-5

Protective effect against ceramide-induced apoptosis

[104]

Hs578T

Cell attachment applications

Cell attachment increased by exogenously added IGFBP-5

[110]

MDA-MB-231

Cellular localization and apoptotic role of IGFBP-5

IGFBP-5 localizes in the nucleus and produces apoptosis

[107]

MDA-MB-231

Role of IGFBP-5 in the apoptotic pathway

IGFBP-5 induces and activates caspase 8 and caspase 9

[108]

Neuroblastoma

B104

Characterization of IGFBP-5 proteases

A specific serine-metalloprotease for IGFBP-5

[122]

LAN-5, N1E-115

Analysis of IGFBP-5 promoter sites

c-Myb and B-Myb enhance IGFBP-5 transcription

[45]

LAN-5, SY5Y(N)

Micro and small interfering RNAs directed to IGFBP-5 mRNA

Growth inhibition and more prone to apoptosis

[123]

Various types of neuroblastoma cells

Retinoic acid-induced differentiation

Increased expression of IGFBP-5

[47,124]

LAN-5, SY5Y(N)

Silencing IGFBP-5

Mitochondrial apoptosis

[125]

Prostate

CWR22, CaP xenograft

Castration and androgen stimulation

Androgen receptor upregulates IGFBP-5

[126]

Mouse androgen-dependent Shionogi tumor model

Castration-induction

Upregulation of IGFBP-5

[97]

LNCaP PC-3

Hormone treatment 1α,25(OH)₂D₃ treatment

No significant effect on IGFBP-5 mRNA level

[127]

IGFBP-5 is primary target gene of the 1 α,25(OH)₂D₃

[128]

Bone marrow stromal cells

Androgen suppression treatment

Increasing IGFBP-5 mRNA expression facilitates prostate cancer progression

[129]

Osteosarcoma

Osteosarcoma U2 cell line, untrans-formed normal human bone cells

Proteolytic degradation of IGFBP-4 and IGFBP-5

Proteolytic activity of IGFBP-5 can modulate IGF action in bone

[130]

Rat osteosarcoma cells

Relationship between growth hormone receptor and IGFBP-5

IGFBP-5 increases growth hormone receptor mRNA and growth hormone binding and potentiates mitogenesis

[131]

OS/50-K8 mouse osteosarcoma cells

Biological activity of IGFBP-5

IGFBP-5 reduces proliferation and regulates differentiation

[132]

U2 human osteosarcoma cells

Examination of IGFBP-5 proteases

ADAM-9 cleaved IGFBP-5 specifically and is v

[133]

Bone cells

Silencing of IGFBP-5

Knockdown of IGFBP-5 induced DNA synthesis and reduced differentiation

[134]

U2 human osteosarcoma cells

Detection of IGFBP-5 interacting proteins

A novel IGFBP-5 interacting protein (IGFBP5-IP)

[135]

LSaOS human osteosarcoma cell line

IGFBP-5 regulations in bone

Four-and-a-half LIM protein 2 and ADAM-9 are major modulators of IGFBP-5 actions

[136]

Ovarian

Human ovarian carcinoma lines

IGFBP levels

Expression of IGFBP-5 appears as a rather rare event

[137]

Ovarian

Various types of ovarian cancers

Examine IGFBP-2 and IGFBP-5 levels

Overexpression of IGFBP-5 in high-grade ovarian carcinoma

[138]

Ovarian cancer patients

Evaluate predictive value of IGFBPs in aromatase inhibitor letrozole

IGFBP-5 is a predictive marker for endocrine therapy

[139]

Cervical

HPV(-) C33A, HPV(+) CaSki cells

Retinoic acid treatment

IGFBP-5 overexpression determines retinoic acid effects in human papilloma virus(-) cells

[48]

Squamous cell carcinomas

Cervical carcinogenesis

Downregulation of IGFBP-5

[140]

Colon

LoVo cells

NS398 treatment

IGFBP-5 might be a target of NS398

[141]

Colon epithelial cells

Leptin treatment

Downregulation of IGFBP-5 by leptin treatment

[142]

Renal

Oncocytomas, clear cell and papillary renal cell carcinoma

Changes of IGF/IGFBPs

Downregulation of IGFBP-5 in papillary renal cell carcinoma and oncocytomas

[143]

Clear cell renal cell carcinoma

Analysis of IGF-axis components

Downregulation of IGFBP-5

[144]

Lung

Lun squamous cell carcinomas, and normal bronchial epithelial tissues

Identification of differentially expressed genes

Overexpression of IGFBP-5

[145]

Gastric

A panel of human gastric cancer cell lines, and normal and tumor tissues

Detect IGFs and IGFBP levels

One-half of the tumor cells express IGFBP-5

[146]

Thyroid

Various types of thyroid tissues

IGFBP-5 levels

Overexpression of IGFBP-5 in papillary carcinoma

[98]

Pancreas

Pancreatic ductal adenocarcinoma

Differential expression of genes

Overexpression of IGFBP-5

[147]

1α,25(OH) ₂D₃ = 1α,25-dihydroxyvitamin D₃; IGF = insulin-like growth factor; IGFBP = insulin-like growth factor binding protein.

Akkiprik et al. Breast Cancer Research 2008 10:212   doi:10.1186/bcr2116