Regulation of cancer stem cells by p53

doi:10.1186/bcr2133

Breast Cancer Research

Volume 10
Issue 4

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Regulation of cancer stem cells by p53

D Joseph Jerry¹^,2 , Luwei Tao¹ and Haoheng Yan¹

¹Department of Veterinary & Animal Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA

²Pioneer Valley Life Sciences Institute, Springfield, MA 01199, USA

author email corresponding author email

Breast Cancer Research 2008, 10:304doi:10.1186/bcr2133


Published:	29 August 2008

Abstract

The hypothesis that cancer stem cells are responsible for the chemoresistant and metastatic phenotypes of many breast cancers has gained support using cell-sorting strategies to enrich the tumor-initiating population of cells. The mechanisms regulating the cancer stem cell pool, however, are less clear. Two recent publications suggest that loss of p53 permits expansion of presumptive cancer stem cells in mouse mammary tumors and in human breast cell lines. These results add restriction of cancer stem cells as a new tumor suppressor activity attributed to p53.