|
HSD11B1 SNP and haplotype associations with breast cancer |
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| Matching adjusteda |
Multivariate adjustedb |
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| SNP |
Alleles |
Cases |
Controls |
OR |
(95% CI) |
P valuec |
OR |
(95% CI) |
P valuec |
|
|
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| HSD11B1 |
rs4393158 |
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| G/G |
563 |
578 |
1.00 |
(-) |
1.00 |
(-) |
|||
| G/A |
65 |
61 |
1.10 |
(0.76–1.59) |
1.09 |
(0.75–1.59) |
|||
| A/A |
2 |
0 |
- |
(-) |
0.39 |
- |
(-) |
0.44 |
|
| G/A or A/A |
67 |
61 |
1.14 |
(0.79–1.64) |
0.5 |
1.13 |
(0.77–1.64) |
0.55 |
|
| rs17317033 |
|||||||||
| A/A |
502 |
493 |
1.00 |
(-) |
1.00 |
(-) |
|||
| A/C |
100 |
126 |
0.78 |
(0.58–1.04) |
0.77 |
(0.57–1.04) |
|||
| C/C |
9 |
4 |
2.16 |
(0.66–7.09) |
0.37 |
1.75 |
(0.52–5.83) |
0.26 |
|
| A/C or C/C |
109 |
130 |
0.82 |
(0.62–1.09) |
0.18 |
0.80 |
(0.60–1.07) |
0.14 |
|
| rs2235543 |
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| C/C |
489 |
510 |
1.00 |
(-) |
1.00 |
(-) |
|||
| C/T |
143 |
128 |
1.17 |
(0.89–1.53) |
1.17 |
(0.89–1.54) |
|||
| T/T |
11 |
13 |
0.88 |
(0.39–1.99) |
0.44 |
0.90 |
(0.39–2.05) |
0.44 |
|
| C/T or T/T |
154 |
141 |
1.14 |
(0.88–1.48) |
0.32 |
1.14 |
(0.88–1.49) |
0.33 |
|
| rs11807619 |
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| G/G |
419 |
471 |
1.00 |
(-) |
1.00 |
(-) |
|||
| G/T |
197 |
159 |
1.39 |
(1.08–1.78) |
1.41 |
(1.10–1.82) |
|||
| T/T |
22 |
18 |
1.34 |
(0.71–2.55) |
0.012 |
1.37 |
(0.71–2.63) |
0.01 |
|
| G/T or T/T |
219 |
177 |
1.38 |
(1.09–1.76) |
0.008 |
1.41 |
(1.10–1.80) |
0.006 |
|
| rs932335 |
|||||||||
| G/G |
349 |
421 |
1.00 |
(-) |
1.00 |
(-) |
|||
| G/C |
234 |
185 |
1.52 |
(1.20–1.94) |
1.56 |
(1.22–2.00) |
|||
| C/C |
30 |
20 |
1.75 |
(0.98–3.15) |
0.0003 |
1.83 |
(1.01–3.33) |
0.0002 |
|
| G/C or C/C |
264 |
205 |
1.55 |
(1.23–1.95) |
0.0002 |
1.59 |
(1.25–2.02) |
0.0001 |
|
|
|
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| Haplotypes of rs11807619 and rs932235 |
GG |
488.7 |
532.9 |
1.00 |
(-) |
1.00 |
(-) |
||
| TC |
120.3 |
97.3 |
1.35 |
(1.09–1.66) |
0.0055 |
1.37 |
(1.11–1.70) |
0.0040 |
|
| GC |
33.4 |
24.2 |
1.54 |
(1.04–2.28) |
0.030 |
1.62 |
(1.08–2.41) |
0.019 |
|
| TG |
0.6 |
0.6 |
0.89 |
(0.06–14.39) |
0.93 |
0.96 |
(0.06–15.81) |
0.98 |
|
| Global P value = 0.01 |
Global P value = 0.006 |
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|
aAdjusted for race, birth date, and blood draw date. bAdjusted for race, birth date, blood draw date, adult weight change, breast cysts, family history of breast cancer, and hormone replacement therapy use. cFor HSD11B1 P values are provided for the log-additive model, and the dominant model; for Haplotypes of rs11807619 and rs932235, haplotype P values are compared with the most common haplotype. CI, confidence interval; HSD11B1, 11β hydroxysteroid dehydrogenase type 1 gene; OR, odds ratio. | |||||||||
Feigelson et al. Breast Cancer Research 2008 10:R57 doi:10.1186/bcr2114 |
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