Table 4 |
|||||||||
|
Mean body mass index and adult weight change by IRS2 SNPs |
|||||||||
| IRS2 SNP |
Cases |
Controls |
|||||||
|
|
|||||||||
| BMI |
Adult weight changea |
BMI |
Adult weight changea |
||||||
| Mean |
(SE) |
Mean |
(SE) |
Mean |
(SE) |
Mean |
(SE) |
||
|
|
|||||||||
| rs9515118 |
G/G |
24.98 |
(0.23) |
26.92 |
(1.33) |
25.48 |
(0.22) |
26.48 |
(1.29) |
| G/C |
25.66 |
(0.32) |
30.94 |
(1.85) |
25.57 |
(0.32) |
27.6 |
(1.83) |
|
| C/C |
25.23 |
(0.85) |
25.36 |
(4.90) |
25.57 |
(0.98) |
33.07 |
(5.64) |
|
| P trend |
0.16 |
0.29 |
0.82 |
0.31 |
|||||
| rs4773082 |
T/T |
25.41 |
(0.37) |
26.56 |
(2.11) |
25.12 |
(0.32) |
25.87 |
(1.81) |
| T/C |
25.2 |
(0.25) |
27.81 |
(1.44) |
25.64 |
(0.27) |
27.43 |
(1.51) |
|
| C/C |
25.17 |
(0.37) |
29.77 |
(2.07) |
25.8 |
(0.38) |
28.07 |
(2.16) |
|
| P trend |
0.64 |
0.28 |
0.15 |
0.42 |
|||||
| rs2289046 |
A/A |
25.49 |
(0.28) |
30.71 |
(1.55) |
25.54 |
(0.29) |
27.5 |
(1.65) |
| A/G |
24.97 |
(0.29) |
26.09 |
(1.66) |
25.52 |
(0.27) |
27.06 |
(1.52) |
|
| G/G |
25.18 |
(0.82) |
22.46 |
(4.60) |
24.98 |
(0.60) |
22.68 |
(3.39) |
|
| P trend |
0.28 |
0.016 |
0.53 |
0.31 |
|||||
| rs754204 |
C/C |
24.99 |
(0.37) |
24.42 |
(2.10) |
25.13 |
(0.32) |
25.45 |
(1.84) |
| C/T |
25.2 |
(0.25) |
27.65 |
(1.43) |
25.57 |
(0.26) |
27.39 |
(1.46) |
|
| T/T |
25.55 |
(0.36) |
31.77 |
(2.04) |
25.9 |
(0.38) |
28.38 |
(2.18) |
|
| P trend |
0.28 |
0.012 |
0.12 |
0.29 |
|||||
| rs7987237 |
C/C |
25.17 |
(0.21) |
28.3 |
(1.20) |
25.58 |
(0.21) |
27.24 |
(1.17) |
| C/T |
25.44 |
(0.37) |
26.95 |
(2.09) |
25.24 |
(0.38) |
25.89 |
(2.13) |
|
| T/T |
25.1 |
(1.18) |
25.73 |
(6.66) |
25.51 |
(1.44) |
34.45 |
(8.16) |
|
| P trend |
0.62 |
0.51 |
0.48 |
0.94 |
|||||
| rs12584136 |
C/C |
25.16 |
(0.19) |
27.36 |
(1.08) |
25.54 |
(0.19) |
27.02 |
(1.07) |
| C/A |
26.36 |
(0.63) |
35.86 |
(3.56) |
24.97 |
(0.61) |
25.58 |
(3.49) |
|
| A/A |
25.52 |
(2.28) |
34.05 |
(12.85) |
30.06 |
(2.60) |
57.32 |
(14.83) |
|
| P trend |
0.1 |
0.026 |
0.95 |
0.61 |
|||||
| rs9559648 |
C/C |
25.34 |
(0.28) |
27.65 |
(1.59) |
25.38 |
(0.26) |
26.05 |
(1.48) |
| C/T |
25.26 |
(0.26) |
28.86 |
(1.49) |
25.61 |
(0.28) |
27.84 |
(1.59) |
|
| T/T |
24.61 |
(0.57) |
25.55 |
(3.20) |
25.64 |
(0.53) |
27.16 |
(3.02) |
|
| P trend |
0.34 |
0.87 |
0.54 |
0.53 |
|||||
| rs9559654 |
G/G |
25.05 |
(0.26) |
26.14 |
(1.49) |
25.68 |
(0.26) |
27.39 |
(1.46) |
| G/A |
25.2 |
(0.29) |
28.47 |
(1.64) |
25.19 |
(0.29) |
26.63 |
(1.64) |
|
| A/A |
25.74 |
(0.56) |
31.38 |
(3.15) |
25.64 |
(0.59) |
25.8 |
(3.36) |
|
| P trend |
0.3 |
0.1 |
0.47 |
0.62 |
|||||
| rs7997595 |
C/C |
25.38 |
(0.22) |
29.46 |
(1.25) |
25.39 |
(0.21) |
26.26 |
(1.21) |
| C/G |
24.83 |
(0.36) |
25.5 |
(2.05) |
25.83 |
(0.35) |
28.77 |
(2.00) |
|
| G/G |
25.58 |
(1.04) |
25.76 |
(5.94) |
25.91 |
(1.58) |
33.47 |
(9.08) |
|
| P trend |
0.38 |
0.11 |
0.27 |
0.2 |
|||||
| rs7981705 |
C/C |
25.2 |
(0.22) |
27.1 |
(1.24) |
25.3 |
(0.21) |
26.3 |
(1.19) |
| C/T |
25.2 |
(0.33) |
29.07 |
(1.88) |
25.84 |
(0.35) |
28.28 |
(2.03) |
|
| T/T |
26.24 |
(1.10) |
34.9 |
(6.22) |
27.62 |
(1.04) |
32.52 |
(5.90) |
|
| P trend |
0.63 |
0.18 |
0.026 |
0.22 |
|||||
| rs4773092 |
G/G |
25.25 |
(0.38) |
8.65 |
(2.14) |
25.66 |
(0.35) |
26.36 |
(2.01) |
| G/A |
25.22 |
(0.25) |
28.19 |
(1.42) |
25.3 |
(0.26) |
26.78 |
(1.52) |
|
| A/A |
25.28 |
(0.40) |
27.03 |
(2.26) |
25.85 |
(0.42) |
28.5 |
(2.41) |
|
| P trend |
0.96 |
0.61 |
0.86 |
0.52 |
|||||
|
|
|||||||||
|
All results are age-adjusted. aAdult weight change is measured in pounds (lbs) from the weight at age 18 years to the weight in 1992. BMI, body mass index; IRS2, insulin receptor substrate 2 gene; SE, standard error. |
|||||||||
|
Feigelson et al. Breast Cancer Research 2008 10:R57 doi:10.1186/bcr2114 |
|||||||||
