Table 8 |
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|
The sensitivities, specificities, and positive and negative predictive values calculated with a Manchester Scoring System cut-off score of ≥ 10 for each gene and ≥ 15 combined, and for BOADICEA score of ≥ 0.10 for each gene and ≥ 0.10 combined (ie, 10% probability of carrying a deleterious mutation) |
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| Manchester Scoring System |
BOADICEA |
|||||
|
|
||||||
| BRCA1 |
BRCA2 |
Combined |
BRCA1 |
BRCA2 |
Combined |
|
|
|
||||||
| Area under the receiver operating curves |
0.74 |
0.82 |
0.80 |
0.82 |
0.56 |
0.73 |
| Standard error |
0.078 |
0.079 |
0.06 |
0.070 |
0.093 |
0.061 |
| 95% CI |
0.67 – 0.81 |
0.75 – 0.88 |
0.72 – 0.86 |
0.75 – 0.88 |
0.48 – 0.64 |
0.65 – 0.80 |
| P valuea |
0.0018 |
0.0001 |
0.0001 |
0.0001 |
0.507 |
0.0001 |
| Sensitivity |
57% |
55% |
72% |
57% |
9% |
40% |
| Specificity |
76% |
87% |
74% |
93% |
93% |
85% |
| Positive-predictive value |
20% |
25% |
37% |
47% |
10% |
36% |
| Negative-predictive value |
94% |
96% |
93% |
95% |
93% |
87% |
|
|
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|
aP value is the probability that the sample area under the ROC curve is found when in fact, the true area under the ROC curve is 0.5 (i.e. null hypothesis: Area = 0.5). |
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|
Thirthagiri et al. Breast Cancer Research 2008 10:R59 doi:10.1186/bcr2118 |
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