Table 3 |
||||||||
|
Ox-E/ER gene signature |
||||||||
|
Affymetrix probe set ID |
UniGene symbol |
E/ER sensitivity |
Oxidant sensitivity |
Fold change |
||||
|
|
||||||||
|
E deprivation |
ER-α knockdown |
8 hours diamide |
8 hours H2O2 |
8 hours menadione |
||||
|
|
||||||||
|
213245_at |
ADCY1 |
E/ER Induced |
Repressed |
0.38 |
0.46 |
0.56 |
0.36 |
0.57 |
|
212136_at |
ATP2B4 |
E/ER Induced |
Repressed |
0.54 |
0.52 |
0.53 |
0.50 |
0.55 |
|
203685_at |
BCL2 |
E/ER Induced |
Repressed |
0.25 |
0.39 |
0.66 |
0.43 |
0.56 |
|
213605_s_at |
C6orf216 |
E/ER Induced |
Repressed |
0.47 |
0.48 |
0.53 |
0.63 |
0.60 |
|
219174_at |
CCDC2 |
E/ER Induced |
Repressed |
0.49 |
0.66 |
0.64 |
0.61 |
0.47 |
|
206280_at |
CDH18 |
E/ER Induced |
Repressed |
0.37 |
0.49 |
0.45 |
0.37 |
0.36 |
|
204135_at |
DOC1 |
E/ER Induced |
Repressed |
0.48 |
0.50 |
0.46 |
0.51 |
0.26 |
|
214240_at |
GAL |
E/ER Induced |
Induced |
0.27 |
0.42 |
1.84 |
1.82 |
2.04 |
|
210640_s_at |
GPR30 |
E/ER Induced |
Repressed |
0.19 |
0.60 |
0.46 |
0.36 |
0.27 |
|
211829_s_at |
GPR30 |
E/ER Induced |
Repressed |
0.29 |
0.44 |
0.43 |
0.35 |
0.33 |
|
204237_at |
GULP1 |
E/ER Induced |
Repressed |
0.44 |
0.56 |
0.65 |
0.62 |
0.49 |
|
204235_s_at |
GULP1 |
E/ER Induced |
Repressed |
0.46 |
0.64 |
0.64 |
0.60 |
0.48 |
|
215913_s_at |
GULP1 |
E/ER Induced |
Repressed |
0.50 |
0.64 |
0.61 |
0.59 |
0.53 |
|
207719_x_at |
KIAA0470 |
E/ER Induced |
Repressed |
0.59 |
0.63 |
0.57 |
0.61 |
0.58 |
|
207358_x_at |
MACF1 |
E/ER Induced |
Repressed |
0.52 |
0.51 |
0.66 |
0.61 |
0.61 |
|
203037_s_at |
MTSS1 |
E/ER Induced |
Repressed |
0.50 |
0.63 |
0.59 |
0.39 |
0.32 |
|
214156_at |
MYRIP |
E/ER Induced |
Repressed |
0.40 |
0.51 |
0.48 |
0.38 |
0.36 |
|
212462_at |
MYST4 |
E/ER Induced |
Repressed |
0.52 |
0.53 |
0.63 |
0.66 |
0.36 |
|
215643_at |
SEMA3D |
E/ER Induced |
Repressed |
0.36 |
0.39 |
0.51 |
0.35 |
0.39 |
|
220038_at |
SGK3 |
E/ER Induced |
Repressed |
0.15 |
0.34 |
0.61 |
0.32 |
0.32 |
|
207586_at |
SHH |
E/ER Induced |
Repressed |
0.16 |
0.32 |
0.59 |
0.53 |
0.37 |
|
216504_s_at |
SLC39A8 |
E/ER Induced |
Repressed |
0.37 |
0.55 |
0.66 |
0.49 |
0.61 |
|
209921_at |
SLC7A11 |
E/ER Induced |
Induced |
0.37 |
0.38 |
1.68 |
11.09 |
8.82 |
|
217678_at |
SLC7A11 |
E/ER Induced |
Induced |
0.37 |
0.52 |
2.18 |
13.46 |
11.81 |
|
201195_s_at |
SLC7A5 |
E/ER Induced |
Induced |
0.35 |
0.51 |
1.60 |
1.72 |
1.78 |
|
212353_at |
SULF1 |
E/ER Induced |
Repressed |
0.36 |
0.45 |
0.52 |
0.44 |
0.46 |
|
203998_s_at |
SYT1 |
E/ER Induced |
Repressed |
0.57 |
0.54 |
0.52 |
0.53 |
0.49 |
|
208161_s_at |
ABCC3 |
E/ER Repressed |
Induced |
7.30 |
4.63 |
1.78 |
2.29 |
3.11 |
|
209641_s_at |
ABCC3 |
E/ER Repressed |
Induced |
7.91 |
3.94 |
1.79 |
2.50 |
3.46 |
|
203196_at |
ABCC4 |
E/ER Repressed |
Induced |
3.08 |
4.16 |
1.93 |
1.93 |
2.31 |
|
206561_s_at |
AKR1B10 |
E/ER Repressed |
Induced |
2.93 |
3.00 |
3.26 |
5.25 |
9.07 |
|
203180_at |
ALDH1A3 |
E/ER Repressed |
Induced |
9.43 |
8.26 |
3.07 |
5.80 |
6.94 |
|
205965_at |
BATF |
E/ER Repressed |
Induced |
2.35 |
2.02 |
1.51 |
1.98 |
2.07 |
|
207996_s_at |
C18orf1 |
E/ER Repressed |
Repressed |
5.71 |
2.07 |
0.49 |
0.36 |
0.47 |
|
213618_at |
CENTD1 |
E/ER Repressed |
Induced |
3.27 |
2.17 |
1.65 |
2.18 |
3.28 |
|
218182_s_at |
CLDN1 |
E/ER Repressed |
Induced |
2.48 |
2.64 |
2.77 |
5.43 |
5.28 |
|
221059_s_at |
COTL1 |
E/ER Repressed |
Induced |
2.45 |
1.81 |
1.56 |
1.59 |
1.82 |
|
209101_at |
CTGF |
E/ER Repressed |
Induced |
8.30 |
4.15 |
1.78 |
3.68 |
15.15 |
|
217028_at |
CXCR4 |
E/ER Repressed |
Repressed |
3.22 |
2.82 |
0.47 |
0.56 |
0.30 |
|
205749_at |
CYP1A1 |
E/ER Repressed |
Induced |
3.28 |
0.55 |
6.75 |
8.96 |
33.02 |
|
210757_x_at |
DAB2 |
E/ER Repressed |
Repressed |
3.25 |
1.51 |
0.51 |
0.60 |
0.43 |
|
201279_s_at |
DAB2 |
E/ER Repressed |
Repressed |
3.45 |
1.67 |
0.47 |
0.56 |
0.39 |
|
201278_at |
DAB2 |
E/ER Repressed |
Repressed |
4.26 |
1.99 |
0.47 |
0.53 |
0.45 |
|
201280_s_at |
DAB2 |
E/ER Repressed |
Repressed |
4.89 |
2.30 |
0.42 |
0.42 |
0.32 |
|
201694_s_at |
EGR1 |
E/ER Repressed |
Induced |
5.77 |
4.42 |
1.73 |
3.03 |
2.52 |
|
219850_s_at |
EHF |
E/ER Repressed |
Repressed |
4.14 |
3.96 |
0.43 |
0.35 |
0.35 |
|
220625_s_at |
ELF5 |
E/ER Repressed |
Repressed |
2.27 |
2.12 |
0.49 |
0.53 |
0.39 |
|
220624_s_at |
ELF5 |
E/ER Repressed |
Repressed |
2.38 |
2.35 |
0.54 |
0.53 |
0.38 |
|
201324_at |
EMP1 |
E/ER Repressed |
Induced |
15.49 |
8.23 |
1.55 |
1.80 |
2.49 |
|
202949_s_at |
FHL2 |
E/ER Repressed |
Induced |
1.63 |
1.56 |
2.15 |
3.87 |
5.07 |
|
213144_at |
GOSR2 |
E/ER Repressed |
Induced |
1.81 |
1.86 |
1.93 |
1.95 |
1.72 |
|
212444_at |
GPCR5A |
E/ER Repressed |
Induced |
3.73 |
2.33 |
1.51 |
2.51 |
1.65 |
|
203108_at |
GPRC5A |
E/ER Repressed |
Induced |
2.46 |
2.07 |
1.57 |
2.58 |
1.70 |
|
203424_s_at |
IGFBP5 |
E/ER Repressed |
Repressed |
2.81 |
1.99 |
0.52 |
0.48 |
0.47 |
|
211959_at |
IGFBP5 |
E/ER Repressed |
Repressed |
3.11 |
2.23 |
0.48 |
0.40 |
0.41 |
|
203287_at |
LAD1 |
E/ER Repressed |
Induced |
1.70 |
1.86 |
1.79 |
1.81 |
2.20 |
|
216641_s_at |
LAD1 |
E/ER Repressed |
Induced |
1.72 |
1.94 |
1.65 |
1.56 |
2.21 |
|
218574_s_at |
LMCD1 |
E/ER Repressed |
Induced |
3.47 |
1.60 |
1.58 |
1.64 |
2.44 |
|
209679_s_at |
LOC57228 |
E/ER Repressed |
Induced |
3.49 |
2.47 |
1.82 |
1.73 |
2.17 |
|
209373_at |
MALL |
E/ER Repressed |
Induced |
7.87 |
5.99 |
2.21 |
3.06 |
4.35 |
|
211026_s_at |
MGLL |
E/ER Repressed |
Induced |
2.52 |
2.78 |
3.26 |
2.66 |
4.96 |
|
217996_at |
PHLDA1 |
E/ER Repressed |
Induced |
2.80 |
3.15 |
1.67 |
3.40 |
6.33 |
|
204284_at |
PPP1R3C |
E/ER Repressed |
Repressed |
3.24 |
2.66 |
0.41 |
0.27 |
0.18 |
|
212636_at |
QKI |
E/ER Repressed |
Repressed |
8.56 |
5.16 |
0.60 |
0.62 |
0.44 |
|
219562_at |
RAB26 |
E/ER Repressed |
Repressed |
1.99 |
3.66 |
0.62 |
0.59 |
0.64 |
|
215321_at |
RPIB9 |
E/ER Repressed |
Repressed |
1.72 |
1.88 |
0.66 |
0.46 |
0.56 |
|
213413_at |
SBLF |
E/ER Repressed |
Repressed |
6.25 |
3.13 |
0.52 |
0.51 |
0.53 |
|
220979_s_at |
ST6GALNAC5 |
E/ER Repressed |
Repressed |
2.87 |
1.55 |
0.64 |
0.61 |
0.66 |
|
205547_s_at |
TAGLN |
E/ER Repressed |
Induced |
2.67 |
4.49 |
4.18 |
3.94 |
8.73 |
|
201506_at |
TGFBI |
E/ER Repressed |
Induced |
4.45 |
2.24 |
1.63 |
2.11 |
2.81 |
|
218368_s_at |
TNFRSF12A |
E/ER Repressed |
Induced |
1.91 |
1.61 |
1.74 |
2.14 |
2.31 |
|
218856_at |
TNFRSF21 |
E/ER Repressed |
Induced |
4.72 |
2.65 |
1.69 |
4.21 |
5.40 |
|
214581_x_at |
TNFRSF21 |
E/ER Repressed |
Induced |
5.81 |
3.41 |
2.08 |
5.43 |
6.63 |
|
216920_s_at |
TRGC2///TRGV9///LOC442532///LOC442670///TARP |
E/ER Repressed |
Repressed |
2.08 |
1.61 |
0.63 |
0.53 |
0.49 |
|
215806_x_at |
TRGC2///TRGV9///LOC442532///LOC442670///TARP |
E/ER Repressed |
Repressed |
2.44 |
1.62 |
0.65 |
0.59 |
0.52 |
|
|
||||||||
|
E, estrogen; ER, estrogen receptor |
||||||||
|
Yau and Benz Breast Cancer Research 2008 10:R61 doi:10.1186/bcr2120 |
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