Breast Cancer Research

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Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures

Pratyaksha Wirapati, Christos Sotiriou*, Susanne Kunkel, Pierre Farmer, Sylvain Pradervand, Benjamin Haibe-Kains, Christine Desmedt, Michail Ignatiadis, Thierry Sengstag, Frédéric Schütz, Darlene R Goldstein, Martine Piccart and Mauro Delorenzi

Breast Cancer Research 2008, 10:R65 doi:10.1186/bcr2124

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Methodology article   Open Access Highly Accessed

Jetset: selecting the optimal microarray probe set to represent a gene

Qiyuan Li, Nicolai J Birkbak, Balazs Gyorffy, Zoltan Szallasi, Aron C Eklund BMC Bioinformatics 2011, 12:474 (15 December 2011)

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Luminal-B breast cancer and novel therapeutic targets

Ben Tran, Philippe L Bedard Breast Cancer Research 2011, 13:221 (30 November 2011)

Research article   Open Access Highly Accessed

Multiple-input multiple-output causal strategies for gene selection

Gianluca Bontempi, Benjamin Haibe-Kains, Christine Desmedt, Christos Sotiriou, John Quackenbush BMC Bioinformatics 2011, 12:458 (25 November 2011)

Research article   Open Access Highly Accessed

A clinically relevant gene signature in triple negative and basal-like breast cancer

Achim Rody, Thomas Karn, Cornelia Liedtke, Lajos Pusztai, Eugen Ruckhaeberle, Lars Hanker, Regine Gaetje, Christine Solbach, Andre Ahr, Dirk Metzler, Marcus Schmidt, Volkmar Müller, Uwe Holtrich, Manfred Kaufmann Breast Cancer Research 2011, 13:R97 (6 October 2011)

Research article   Open Access

Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response

Qiyuan Li, Aron C Eklund, Nicolai J Birkbak, Christine Desmedt, Benjamin Haibe-Kains, Christos Sotiriou, W Fraser Symmans, Lajos Pusztai, Søren Brunak, Andrea L Richardson, Zoltan Szallasi BMC Bioinformatics 2011, 12:310 (28 July 2011)

Software   Open Access

A simple method for assigning genomic grade to individual breast tumours

Kristian Wennmalm, Jonas Bergh BMC Cancer 2011, 11:306 (21 July 2011)

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Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction

Pierre-Emmanuel Colombo, Fernanda Milanezi, Britta Weigelt, Jorge S Reis-Filho Breast Cancer Research 2011, 13:212 (27 June 2011)

In this review, the authors examine the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management.

Short communication   Free

Molecular profiling contributes more than routine histology and immonohistochemistry to breast cancer diagnostics

Christine Shiang, Lajos Pusztai Breast Cancer Research 2010, 12(Suppl 4):S6 (20 December 2010)

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Molecular profiling currently offers no more than tumour morphology and basic immunohistochemistry

Britta Weigelt, Jorge S Reis-Filho Breast Cancer Research 2010, 12(Suppl 4):S5 (20 December 2010)

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Breast cancer prognostic classification in the molecular era: the role of histological grade

Emad A Rakha, Jorge S Reis-Filho, Frederick Baehner, David J Dabbs, Thomas Decker, Vincenzo Eusebi, Stephen B Fox, Shu Ichihara, Jocelyne Jacquemier, Sunil R Lakhani, José Palacios, Andrea L Richardson, Stuart J Schnitt, Fernando C Schmitt, Puay-Hoon Tan, Gary M Tse, Sunil Badve, Ian O Ellis Breast Cancer Research 2010, 12:207 (30 July 2010)

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High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer

Johan Staaf, Göran Jönsson, Markus Ringnér, Johan Vallon-Christersson, Dorthe Grabau, Adalgeir Arason, Haukur Gunnarsson, Bjarni A Agnarsson, Per-Olof Malmström, Oskar Johannsson, Niklas Loman, Rosa B Barkardottir, Åke Borg Breast Cancer Research 2010, 12:R25 (6 May 2010)

A survey of copy number alterations in HER2+ breast tumors using a combination of array comparative genomic hybridization and gene expression analyses pinpoints significant genomic aberrations, including potentially novel therapeutic targets.

Method   Open Access

A fuzzy gene expression-based computational approach improves breast cancer prognostication

Benjamin Haibe-Kains, Christine Desmedt, Françoise Rothé, Martine Piccart, Christos Sotiriou, Gianluca Bontempi Genome Biology 2010, 11:R18 (15 February 2010)

A fuzzy computational approach that takes into account several molecular subtypes in order to provide more accurate breast cancer prognosis

Research article   Open Access Highly Accessed

Molecular risk assessment of BIG 1-98 participants by expression profiling using RNA from archival tissue

Janine Antonov, Vlad Popovici, Mauro Delorenzi, Pratyaksha Wirapati, Anna Baltzer, Andrea Oberli, Beat Thürlimann, Anita Giobbie-Hurder, Giuseppe Viale, Hans Altermatt, Stefan Aebi, Rolf Jaggi BMC Cancer 2010, 10:37 (9 February 2010)

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Effect of training-sample size and classification difficulty on the accuracy of genomic predictors

Vlad Popovici, Weijie Chen, Brandon D Gallas, Christos Hatzis, Weiwei Shi, Frank W Samuelson, Yuri Nikolsky, Marina Tsyganova, Alex Ishkin, Tatiana Nikolskaya, Kenneth R Hess, Vicente Valero, Daniel Booser, Mauro Delorenzi, Gabriel N Hortobagyi, Leming Shi, W Fraser Symmans, Lajos Pusztai Breast Cancer Research 2010, 12:R5 (11 January 2010)

Short communication   Free

Gene expression profiling of breast cancer

Lajos Pusztai Breast Cancer Research 2009, 11(Suppl 3):S11 (18 December 2009)

Proceedings   Open Access

HPD: an online integrated human pathway database enabling systems biology studies

Sudhir R Chowbina, Xiaogang Wu, Fan Zhang, Peter M Li, Ragini Pandey, Harini N Kasamsetty, Jake Y Chen BMC Bioinformatics 2009, 10(Suppl 11):S5 (8 October 2009)

Methodology article   Open Access

Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues

Jérôme Toussaint, Anieta M Sieuwerts, Benjamin Haibe-Kains, Christine Desmedt, Ghizlane Rouas, Adrian L Harris, Denis Larsimont, Martine Piccart, John A Foekens, Virginie Durbecq, Christos Sotiriou BMC Genomics 2009, 10:424 (10 September 2009)

Research article   Open Access

Relationship between estrogen receptor α location and gene induction reveals the importance of downstream sites and cofactors

Fabio Parisi, Bernhard Sonderegger, Pratyaksha Wirapati, Mauro Delorenzi, Felix Naef BMC Genomics 2009, 10:381 (18 August 2009)

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Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer

Sherene Loi, Christos Sotiriou, Benjamin Haibe-Kains, Francoise Lallemand, Nelly M Conus, Martine J Piccart, Terence P Speed, Grant A McArthur BMC Medical Genomics 2009, 2:37 (24 June 2009)

Activation of growth factor (GF) signalling contributes to the tamoxifen-insensitive estrogen receptor-positive breast cancer phenotype independent of human epidermal growth factor receptor (HER2) gene expression, suggesting an alternative therapeutic target for this aggressive disease.

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T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers

Achim Rody, Uwe Holtrich, Laos Pusztai, Cornelia Liedtke, Regine Gaetje, Eugen Ruckhaeberle, Christine Solbach, Lars Hanker, Andre Ahr, Dirk Metzler, Knut Engels, Thomas Karn, Manfred Kaufmann Breast Cancer Research 2009, 11:R15 (9 March 2009)

The T-cell metagene LCK identifies ER negative breast cancers, commonly associated with poor disease free survival, and may also identify differences in prognosis within this tumor subtype.

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Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells

Bérengère Marty, Virginie Maire, Eléonore Gravier, Guillem Rigaill, Anne Vincent-Salomon, Marion Kappler, Ingrid Lebigot, Fathia Djelti, Audrey Tourdès, Pierre Gestraud, Philippe Hupé, Emmanuel Barillot, Francisco Cruzalegui, Gordon C Tucker, Marc-Henri Stern, Jean-Paul Thiery, John A Hickman, Thierry Dubois Breast Cancer Research 2008, 10:R101 (3 December 2008)