Table 3

Mean percentage mammographic density (MD) according to breast cancer susceptibility loci, Nurses' Health Study controls (1989–1998)


Premenopausal (n = 217)
 Postmenopausal (n = 904)


N
 Mean %MDa
 Mean %MDb
 N
 Mean %MDa
 Mean %MDc
rs2981582
 G/G
 73
 37.4
 37.9
 332
 24.4
 24.2

G/A
 112
 40.5
 40.7
 407
 23.9
 23.6

A/A
 28
 41.7
 38.4
 131
 23.7
 25.3
p value d

0.27
 0.62
0.34
 0.82
rs12443621
 A/A
 51
 36.0
 36.2
 236
 22.9
 23.4

A/G
 104
 38.9
 39.1
 442
 24.5
 24.2

G/G
 54
 43.7
 42.5
 202
 23.5
 23.8
p value d

0.05
 0.06
0.70
 0.72
rs13281615
 A/A
 70
 39.7
 38.2
 290
 25.2
 25.0

A/G
 94
 36.0
 38.2
 445
 23.7
 23.9

G/G
 47
 45.8
 43.1
 144
 22.9
 22.8
p value d

0.45
 0.52
0.36
 0.32
rs3817198
 A/A
 80
 33.9
 33.5
 396
 24.2
 24.0

A/G
 106
 42.6
 42.3
 368
 24.4
 24.6

G/G
 20
 39.5
 41.0
 93
 22.7
 22.8
p value d

0.04
 0.01
0.39
 0.56
rs889312
 T/T
 107
 41.1
 41.3
 499
 25.6
 25.4

T/G
 89
 38.5
 38.2
 321
 21.5
 22.1

G/G
 14
 38.8
 37.2
 58
 26.8
 25.3
p value d

0.40
 0.21
0.17
 0.14
rs4666451
 G/G
 74
 40.7
 41.6
 314
 24.0
 24.5

A/G
 96
 40.6
 39.5
 418
 24.2
 23.8

A/A
 36
 33.0
 33.6
 144
 24.3
 24.3
p value d

0.13
 0.06
0.90
 0.40
rs2107425
 G/G
 105
 41.7
 40.7
 449
 24.3
 24.6

G/A
 87
 36.8
 37.2
 337
 23.4
 23.3

A/A
 18
 37.5
 39.6
 85
 24.6
 23.6
p value d

0.11
 0.29
0.79
 0.37
rs981782
 A/A
 64
 37.7
 37.5
 258
 25.5
 24.6

A/C
 100
 39.4
 39.2
 429
 23.7
 24.1

C/C
 47
 42.3
 42.5
 175
 23.2
 23.4
p value d

0.39
 0.27
0.08
 0.22
rs8051542
 G/G
 63
 41.0
 40.5
 234
 23.2
 23.4

G/A
 73
 40.0
 40.1
 296
 22.3
 22.3

A/A
 32
 37.9
 37.8
 137
 27.6
 27.3
p value d

0.58
 0.65
0.36
 0.43
rs30099
 C/C
 175
 38.8
 38.8
 723
 24.4
 24.5

C/T
 34
 40.5
 39.9
 151
 22.6
 22.4

T/T
 0

8
 26.0
 21.8
p value d

0.45
 0.51
0.49
 0.16
rs3803662
 G/G
 107
 37.0
 36.9
 458
 23.9
 24.1

G/A
 77
 43.9
 42.7
 344
 24.0
 23.4

A/A
 20
 32.7
 36.1
 69
 26.5
 28.0
p value d

0.55
 0.34
0.64
 0.50

aAge adjusted.

bMultivariate adjusted for the following: age (continuous), body mass index (BMI) (continuous), alcohol consumption (none, <5 g/day, 5 to 14.9 g/day, 15+ g/day), age at first birth/parity (nulliparous, age at first birth <25, age at first birth 25 to 29, age at first birth >30), history of benign breast disease (yes/no), family history of breast cancer (yes/no).

cMultivariate adjusted for the following: age, BMI, alcohol consumption, age at first birth/parity, history of benign breast disease, family history of breast cancer, postmenopausal hormone use (never user, current user, past user).

dp value based on genotype coded as ordinal variable regressed on square root transformed MD.

Tamimi et al. Breast Cancer Research 2008 10:R66   doi:10.1186/bcr2127

Open Data