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Comparison of breast cancer risk factors and breast tumour characteristics according to those who were eligible for the study, those for whom we received pathology specimens and those who were included in the tissue microarrays, Nurses' Health Study (1976 to 1996) |
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| Eligible for TMA (n = 5610) |
Received pathology specimens (n = 3752) |
Included in TMA (n = 2897) |
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| Means |
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| Age at diagnosis, y |
56.4 |
57.4 |
57.5 |
| Age at menarche, y |
12.4 |
12.4 |
12.4 |
| Age at first birth, y |
25.4 |
25.4 |
25.3 |
| Age at menopause, y |
46.9 |
47.1 |
47.1 |
| BMI at age 18, kg/m2 |
21.0 |
21.0 |
21.0 |
| Parity |
3.2 |
3.2 |
3.2 |
| Alcohol g/week |
6.6 |
6.1 |
6.2 |
| Frequencies, n (%) |
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| Family history of BC |
805 (14.4) |
559 (14.9) |
409 (14.1) |
| Nulliparous |
430 (7.7) |
281 (7.5) |
211 (7.3) |
| Premenopausal |
1345 (24.0) |
782 (20.8) |
600 (20.7) |
| Prior BBD |
2662 (47.5) |
1852(49.4) |
1360 (47.0) |
| Current PMH user |
1239 (33.8) |
884 (34.2) |
688 (34.6) |
| Year of diagnosis |
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| 1976 to 1980 |
517 (9.4) |
223 (6.1) |
158 (5.6) |
| 1980 to 1985 |
1066 (19.4) |
565 (15.4) |
431 (15.2) |
| 1985 to 1990 |
1678 (30.6) |
1152 (31.3) |
899 (31.6) |
| 1990 to 1996 |
2230 (40.6) |
1739 (47.3) |
1357 (47.7) |
| Tumour characteristicsa |
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| DCIS |
654 (11.7) |
443 (11.8) |
270 (9.3) |
| Invasive |
4956 (88.3) |
3309 (88.2) |
2627 (90.7) |
| Tumour size |
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| Less than 2 cm |
3162 (65.6) |
2197 (66.7) |
1685 (64.9) |
| More than 2 cm |
1656 (34.4) |
1098 (33.3) |
911 (35.1) |
| Grade |
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| Well differentiated |
319 (15.2) |
240 (16.2) |
176 (14.7) |
| Moderately |
860 (41.0) |
630 (42.4) |
515 (43.1) |
| Poorly |
919 (43.8) |
615 (41.4) |
505 (42.2) |
| Nodal involvement |
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| No nodes |
3931 (70.1) |
2684 (71.5) |
2006 (69.2) |
| 1 to 3 nodes |
904 (16.1) |
585 (15.6) |
485 (16.7) |
| 4 to 9 nodes |
428 (7.6) |
268 (7.1) |
213 (7.4) |
| More than 10 nodes |
228 (4.1) |
140 (3.7) |
129 (4.5) |
| Metastatic |
119 (2.1) |
75 (2.0) |
64 (2.2) |
| Receptor status |
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| ER+ |
2738 (74.5) |
1953 (75.2) |
1572 (75.3) |
| PR+ |
2083 (61.2) |
1518 (61.9) |
1235 (62.3) |
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aTumour characteristics abstracted from medical pathology reports. BC, breast cancer; BBD, benign breast disease; BMI, body mass index; DCIS, ductal carcinoma in situ; ER, oestrogen receptor; PMH, postmenopausal hormone; PR, progesterone receptor; TMA, tissue microarrays. | |||
Tamimi et al. Breast Cancer Research 2008 10:R67 doi:10.1186/bcr2128 |
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