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Volume 10 Issue 5
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Comment |
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A gene signature of loss of oestrogen receptor (ER) function and oxidative stress links ER-positive breast tumours with an absent progesterone receptor and a poor prognosis
Patrick Neven, Toon Van Gorp, Karen Deraedt Breast Cancer Research 2008, 10:109 (4 September 2008)
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Breast cancer stem cell markers – the rocky road to clinical applications
Gabriela Dontu Breast Cancer Research 2008, 10:110 (15 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The evolving role of oestrogen receptor beta in clinical breast cancer
Valerie Speirs Breast Cancer Research 2008, 10:111 (19 September 2008)
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On the way to specifically targeting minimal residual disease?
Gerhard Gebauer Breast Cancer Research 2008, 10:112 (7 October 2008)
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Highway to heaven: mammary gland development and differentiation
Lorenzo Melchor, Matthew J Smalley Breast Cancer Research 2008, 10:305 (6 October 2008)
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Review |
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Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models
Christina N Bennett, Jeffrey E Green Breast Cancer Research 2008, 10:213 (11 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer
Charles Swanton, Zoltan Szallasi, James D Brenton, Julian Downward Breast Cancer Research 2008, 10:214 (31 October 2008)
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Report |
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Correction: BCoR-L1 variation and breast cancer
Felicity Lose, Jeremy Arnold, David B Young, Carolyn J Brown, Graham J Mann, Gulietta M Pupo, The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Kum Khanna, Georgia Chenevix-Trench, Amanda B Spurdle Breast Cancer Research 2008, 10:406 (21 October 2008)
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Research |
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A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study
Flavia Novelli, Michele Milella, Elisa Melucci, Anna Di Benedetto, Isabella Sperduti, Raffaele Perrone-Donnorso, Letizia Perracchio, Irene Venturo, Cecilia Nisticò, Alessandra Fabi, Simonetta Buglioni, Pier Natali, Marcella Mottolese Breast Cancer Research 2008, 10:R74 (4 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
Jason I Herschkowitz, Xiaping He, Cheng Fan, Charles M Perou Breast Cancer Research 2008, 10:R75 (9 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The functional loss of the retinoblastoma tumour suppressor, RB1, is common in basal-like tumours and may play a key role in their aggressive biology and unique therapeutic responses.
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ERalpha-status of disseminated tumour cells in bone marrow of primary breast cancer patients
Tanja Fehm, Natalia Krawczyk, Erich-Franz Solomayer, Graziella Becker-Pergola, Silke Dürr-Störzer, Hans Neubauer, Harald Seeger, Annette Staebler, Diethelm Wallwiener, Sven Becker Breast Cancer Research 2008, 10:R76 (15 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Characterisation of disseminated tumor cells (DTCs) in breast cancer patients identified different ERalpha-status to primary tumor cells, which may explain failure rates seen in conventional endocrine adjuvant therapy.
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Clinical feasibility of (neo)adjuvant taxane-based chemotherapy in older patients: analysis of >4,500 patients from four German randomized breast cancer trials
Sibylle Loibl, Gunter von Minckwitz, Nadia Harbeck, Wolfgang Janni, Dirk Elling, Manfred Kaufmann, Holm Eggemann, Valentina Nekljudova, Harald Sommer, Marion Kiechle, Sherko Kümmel Breast Cancer Research 2008, 10:R77 (16 September 2008)
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Menopausal hormone therapy in relation to breast cancer characteristics and prognosis: a cohort study
Lena U Rosenberg, Fredrik Granath, Paul W Dickman, Kristjana Einarsdóttir, Sara Wedrén, Ingemar Persson, Per Hall Breast Cancer Research 2008, 10:R78 (19 September 2008)
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Editor’s summary
Current menopausal hormone therapy use is associated with tumours of low grade and favourable breast cancer survival in a study of over 2,600 post-menopausal women with invasive breast cancer.
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Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
Signe Borgquist, Annika Jögi, Fredrik Pontén, Lisa Rydén, Donal J Brennan, Karin Jirström Breast Cancer Research 2008, 10:R79 (22 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
A reductase enzyme in the mevalonate pathway is associated with prolonged recurrence free survival in ER positive breast cancer, but may have an inverse relationship with prognosis in ER negative tumors.
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Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients
Galatea Kallergi, Sofia Agelaki, Antonia Kalykaki, Christos Stournaras, Dimitris Mavroudis, Vassilis Georgoulias Breast Cancer Research 2008, 10:R80 (29 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer
Katja Lundgren, Karolina Holm, Bo Nordenskjöld, Åke Borg, Göran Landberg Breast Cancer Research 2008, 10:R81 (29 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Wnt signalling in human breast cancer: expression of the putative Wnt inhibitor Dickkopf-3 (DKK3) is frequently suppressed by promoter hypermethylation in mammary tumours
Jürgen Veeck, Nuran Bektas, Arndt Hartmann, Glen Kristiansen, Uwe Heindrichs, Ruth Knüchel, Edgar Dahl Breast Cancer Research 2008, 10:R82 (30 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The putative Wnt signaling inhibitor, Dickkopf-3 (DKK3) is frequently downregulated in breast cancer due to aberrant methylation of the DKK3 promoter, and may be a potential tumour suppressor gene.
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Recurrence dynamics does not depend on the recurrence site
Romano Demicheli, Elia Biganzoli, Patrizia Boracchi, Marco Greco, Michael W Retsky Breast Cancer Research 2008, 10:R83 (9 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central |
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Editor’s summary
Disease course following primary tumour removal follows a common pathway with well-defined steps and the recurrence risk pattern results from inherent features of the metastasis development process, apparently attributable to tumour cells.
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Targeting aspartate aminotransferase in breast cancer
Joshua Thornburg, Kristin K Nelson, Brian F Clem, Andrew N Lane, Sengodagounder Arumugam, Allan Simmons, John W Eaton, Sucheta Telang, Jason Chesney Breast Cancer Research 2008, 10:R84 (15 October 2008)
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Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1
Hans Neubauer, Susan E Clare, Wojciech Wozny, Gerhard P Schwall, Slobodan Poznanović, Werner Stegmann, Ulrich Vogel, Karl Sotlar, Diethelm Wallwiener, Raffael Kurek, Tanja Fehm, Michael A Cahill Breast Cancer Research 2008, 10:R85 (15 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Redefining prognostic factors for breast cancer: YB-1 is a stronger predictor of relapse and disease-specific survival than estrogen receptor or HER-2 across all tumor subtypes
Golareh Habibi, Samuel Leung, Jennifer H Law, Karen Gelmon, Hamid Masoudi, Dmitry Turbin, Michael Pollak, Torsten O Nielsen, David Huntsman, Sandra E Dunn Breast Cancer Research 2008, 10:R86 (16 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Y-box binding protein-1 is superior to estrogen receptor and HER-2 as a prognostic marker for relapse and survival across all breast cancer subtypes, in a study of over 4000 breast cancer cases.
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Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma
Nadia P Castro, Cynthia ABT Osório, César Torres, Elen P Bastos, Mário Mourão-Neto, Fernando A Soares, Helena P Brentani, Dirce M Carraro Breast Cancer Research 2008, 10:R87 (17 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Potentially invasive cells from ductal carcinoma in situ exhibit modifications in the general gene expression pattern before visible morphological alteration of the lesion, predicting the carcinoma progression risk.
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A candidate molecular signature associated with tamoxifen failure in primary breast cancer
Julie A Vendrell, Katherine E Robertson, Patrice Ravel, Susan E Bray, Agathe Bajard, Colin A Purdie, Catherine Nguyen, Sirwan M Hadad, Ivan Bieche, Sylvie Chabaud, Thomas Bachelot, Alastair M Thompson, Pascale A Cohen Breast Cancer Research 2008, 10:R88 (17 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
Elton Rexhepaj, Donal J Brennan, Peter Holloway, Elaine W Kay, Amanda H McCann, Goran Landberg, Michael J Duffy, Karin Jirstrom, William M Gallagher Breast Cancer Research 2008, 10:R89 (23 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
The automated quantification of estrogen and progesterone receptors in 743 primary breast tumours using a novel unsupervised image analysis algorithm provides a useful tool to quantify biomarkers on tissue specimens.
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Selective segregation of DNA strands persists in long label retaining mammary cells during pregnancy
Brian W Booth, Corinne A Boulanger, Gilbert H Smith Breast Cancer Research 2008, 10:R90 (24 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9
Dengfeng Cao, Kornelia Polyak, Marc K Halushka, Hind Nassar, Nina Kouprina, Christine Iacobuzio-Donahue, Xinyan Wu, Saraswati Sukumar, Jessica Hicks, Angelo De Marzo, Pedram Argani Breast Cancer Research 2008, 10:R91 (27 October 2008)
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Prospective study of physical activity and risk of postmenopausal breast cancer
Michael F Leitzmann, Steven C Moore, Tricia M Peters, James V Lacey, Arthur Schatzkin, Catherine Schairer, Louise A Brinton, Demetrius Albanes Breast Cancer Research 2008, 10:R92 (31 October 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Vigorous activity reduces breast cancer risk in lean, postmenopausal women via a mechanism independent of body weight control, indicates a study of over 32,000 women.
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Correspondence |
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Luminal B breast tumors are not HER2 positive
Rohit Bhargava, David J Dabbs Breast Cancer Research 2008, 10:404 (26 September 2008)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Luminal B breast tumors are not HER2 positive – authors' response
Rulla M Tamimi, Stuart J Schnitt, Graham A Colditz, Laura C Collins Breast Cancer Research 2008, 10:405 (26 September 2008)
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