Table 1

Shared genetic and genomic features between mouse models of mammary cancer and human breast tumor subtypes

Mouse model

Shared features

Reference

Mouse genomic changes

Reference

Luminal

p53^fp/fp, WAP-Cre

ER⁺

A.M. Michalowska, unpublished data

MMTV-Neu

ER^-, K8/K18⁺, and XBP1⁺

[7]

MMTV-PyMT

ER^-, K8/K18⁺, XBP1⁺, and GATA3⁺

[7]

WAP-Myc

ER^-, K8/K18⁺, XBP1⁺, and GATA3⁺

[7]

WAP-Int3

ER^-, K8/K18⁺, and GATA3⁺

[7]

Basal-like

C3(1)Tag

ER^-, Her2^-, kRAS2 amplification, K5⁺, proliferation signature, and poor outcome

[6,7]

Chromosome 6

[21]

Brca1^+/-, p53^+/-, IR

K5⁺

[7]

WAP-Tag

Proliferation signature

[7]

Proliferation signature

[7]

WAP-T₁₂₁

Brca1^co/co, MMTV-Cre, p53^+/-

K5⁺

[7]

Chromosomes 4, 11, 14, 15, and X

[29]

DMBA-induced adenocarcinoma

K5⁺

[7]

Her2/Neu

Conditional expression of endogenous Neu and promoter driven-activated Neu

ErbB2 amplification

[32]

Chromosomes 4 and 11

[32,33]

Normal breast

MMTV-Wnt1

K5⁺

[7]

Claudin-low

Tumors with spindle cell morphology, including Brca1^co/co, MMTV-Cre, p53^+/-, DMBA-induced spindle, and p53 null transplant

Low expression: claudins 3, 4, and 7, occlucdin, and e-cadherin

[7]

ER, estrogen receptor.

Bennett and Green Breast Cancer Research 2008 10:213   doi:10.1186/bcr2125