Table 2

Multivariate analyses of negative prognostic factors for disease-free survival

Disease-free survival

Factors

HR (95% CI)

P value

All patients (728)

pT stage (3–4 versus 1–2)

2.51 (1.40–4.50)

0.002

pN stage (positive versus negative)

2.44 (1.62–3.66)

<0.0001

Ki67 (positive versus negative)

1.59 (1.08–2.34)

0.02

Node-positive patients (278)

pT stage (3–4 versus 1–2)

2.51 (1.40–4.50)

0.002

ER-β (positive versus negative)

1.55 (1.93–2.57)

0.09

Node-negative patients (450)

ER-β (negative versus positive)

1.76 (0.95–3.24)

0.07

Ki67 (positive versus negative)

2.16 (1.15–4.04)

0.02

Cox regression analysis using a forward stepwise procedure (enter limit = 0.10, remove limit = 0.15). CI, confidence interval; ER-β, estrogen receptor-beta; HR, hazard ratio; pN, pathological node status; pT, pathological tumor size.

Novelli et al. Breast Cancer Research 2008 10:R74   doi:10.1186/bcr2139