Research article
The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
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* Corresponding author: Charles M Perou cperou@med.unc.edu
1 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
2 Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
3 Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
4 Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, DeBakey M635, Houston, TX 77030, USA
Breast Cancer Research 2008, 10:R75 doi:10.1186/bcr2142
Published: 9 September 2008Additional files
Additional File 1:
A PDF file containing a figure comparing p16INK4a and proliferation gene expression across 13 transgenic murine mammary tumour models.
Format: PDF Size: 1.6MB Download file
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Additional File 2:
A PDF file containing a figure showing a box plot comparison of RB-loss signature relative to the five intrinsic subtypes as defined by the 5-class centroid predictor.
Format: PDF Size: 240KB Download file
This file can be viewed with: Adobe Acrobat Reader
Additional File 3:
A PDF file containing a figure showing a box plot comparison of average expression of a) RB-LOH, b) RB loss, c) proliferation signature and d) 20-gene overlap signature relative to response to neoadjuvant treatment.
Format: PDF Size: 568KB Download file
This file can be viewed with: Adobe Acrobat Reader