Figure 3.

Retinoblastoma (RB) 1 loss of heterozygosity (LOH) is associated with high proliferation. (a) An example of LOH detected in a breast tumour sample at RB1 intron 20. The arrows point to the missing allele with A7-N being DNA from normal tissue and A7-T is tumour DNA from the same patient. (b) Two-way unsupervised hierarchical clustering of breast tumour samples with informative RB1 LOH status (LOH + = blue, LOH - = yellow) using the proliferation gene cluster. (c) Box plot comparison of the average proliferation cluster expression to RB1 LOH status.