Table 2 |
||||
|
Incidence of grade 3 to grade 4 hematologic toxicity, per age interval and per taxane |
||||
| Docetaxel |
Paclitaxel |
Total |
P value, docetaxel versus paclitaxel |
|
|
|
||||
| Leukopenia |
||||
| Patients aged < 60 years |
1,534 (59.6) |
196 (35.3) |
1,730 (55.3) |
<0.001 |
| Patients aged 60 to 64 years |
351 (68.3) |
55 (45.8) |
406 (64.0) |
<0.001 |
| Patients aged > 64 years |
234 (69.2) |
38 (49.4) |
272 (65.5) |
0.001 |
| P value |
<0.001 |
0.011 |
<0.001 |
|
| Neutropenia |
||||
| Patients aged < 60 years |
926 (47.4) |
226 (44.8) |
1,152 (46.9) |
0.321 |
| Patients aged 60 to 64 years |
273 (57.6) |
53 (48.6) |
326 (55.9) |
0.111 |
| Patients aged > 64 years |
190 (59.2) |
35 (49.3) |
225 (57.4) |
0.164 |
| P value |
<0.001 |
0.643 |
<0.001 |
|
| Febrile neutropenia |
||||
| Patients aged <60 years |
179 (7.2) |
2 (0.4) |
181 (6.1) |
<0.001 |
| Patients aged 60 to 64 years |
40 (8.1) |
3 (2.8) |
43 (7.2) |
0.085 |
| Patients aged > 64 years |
28 (8.7) |
1 (1.4) |
29 (7.4) |
0.061 |
| P value |
0.560 |
0.049 |
0.430 |
|
| Anemia |
||||
| Patients aged < 60 years |
57 (2.2) |
40 (7.2) |
97 (3.1) |
<0.001 |
| Patients aged 60 to 64 years |
12 (2.3) |
4 (3.3) |
16 (2.5) |
0.756 |
| Patients aged > 64 years |
12 (3.6) |
2 (2.6) |
14 (3.4) |
0.946 |
| P value |
0.315 |
0.110 |
0.674 |
|
| Thrombopenia |
||||
| Patients aged < 60 years |
44 (1.7) |
26 (4.7) |
70 (2.3) |
<0.001 |
| Patients aged 60 to 64 years |
13 (2.5) |
1 (0.8) |
14 (2.2) |
0.432 |
| Patients aged > 64 years |
21 (6.2) |
0 (0.0) |
21 (5.1) |
0.050 |
| P value |
<0.001 |
0.025 |
0002 |
|
|
|
||||
|
Data presented as n (%). All percentage values are valid. P values all for incidence of difference between age groups. |
||||
|
Loibl et al. Breast Cancer Research 2008 10:R77 doi:10.1186/bcr2144 |
||||
