Table 4 |
|||
|
Nonhematologic toxicity per schedule in patients aged ≥ 60 years, n (%) |
|||
|
Docetaxel |
Paclitaxel |
Total |
|
|
|
|||
|
Fatigue grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,922 (88.4) |
- |
1,922 (88.4) |
|
Patients aged 60 to 64 years |
362 (87.0) |
- |
362 (87.0) |
|
Patients aged >64 years |
235 (90.4) |
- |
235 (90.4) |
|
P value |
0.414 |
- |
0.414 |
|
Fatigue grade 3 to grade 4 |
|||
|
Patients aged <60 years |
315 (14.5) |
- |
315 (14.5) |
|
Patients aged 60 to 64 years |
81 (19.5) |
- |
81 (19.5) |
|
Patients aged >64 years |
61 (23.5) |
- |
61 (23.5) |
|
P value |
<0.001 |
- |
<0.001 |
|
Loss of appetite grade 1 to grade 3 |
|||
|
Patients aged <60 years |
441 (67.0) |
- |
441 (67.0) |
|
Patients aged 60 to 64 years |
110 (73.8) |
- |
110 (73.8) |
|
Patients aged >64 years |
76 (84.4) |
- |
76 (84.4) |
|
P value |
0.002 |
- |
0.002 |
|
Loss of appetite grade 3 |
|||
|
Patients aged <60 years |
76 (11.6) |
- |
76 (11.6) |
|
Patients aged 60 to 64 years |
33 (22.1) |
- |
33 (22.1) |
|
Patients aged >64 years |
18 (20.0) |
- |
18 (20.0) |
|
P value |
0.001 |
- |
0.001 |
|
Nausea/vomiting grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,980 (77.5) |
473 (84.6) |
2,453 (78.8) |
|
Patients aged 60 to 64 years |
410 (79.3) |
101 (85.6) |
511 (80.5) |
|
Patients aged >64 years |
290 (85.5) |
62 (78.5) |
352 (84.2) |
|
P value |
0.003 |
0.337 |
0.028 |
|
Nausea/vomiting grade 3 to grade 4 |
|||
|
Patients aged <60 years |
206 (8.1) |
32 (5.7) |
238 (7.6) |
|
Patients aged 60 to 64 years |
47 (9.1) |
2 (1.7) |
49 (7.7) |
|
Patients aged >64 years |
34 (10.0) |
0 (0.0) |
39 (9.3) |
|
P value |
0.392 |
0.175 |
0.479 |
|
Mucositis grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,736 (68.0) |
299 (53.5) |
2,035 (65.4) |
|
Patients aged 60 to 64 years |
360 (69.9) |
77 (65.3) |
437 (69.0) |
|
Patients aged >64 years |
231 (68.5) |
42 (53.2) |
273 (65.6) |
|
P value |
0.688 |
0.060 |
0.205 |
|
Mucositis grade 3 to grade 4 |
|||
|
Patients aged <60 years |
115 (4.5) |
9 (1.6) |
124 (4.0) |
|
Patients aged 60 to 64 years |
26 (5.0) |
7 (5.9) |
33 (5.2) |
|
Patients aged >64 years |
25 (7.4) |
5 (6.3) |
30 (7.2) |
|
P value |
0.064 |
0.004 |
0.007 |
|
Sensory neuropathy grade 1 to grade 4 |
|||
|
Patients aged <60 years |
39 (1.5) |
15 (2.7) |
54 (1.7) |
|
Patients aged 60 to 64 years |
16 (3.1) |
2 (1.7) |
18 (2.8) |
|
Patients aged >64 years |
6 (1.8) |
3 (3.8) |
9 (2.2) |
|
P value |
0.729 |
0.803 |
0.647 |
|
Sensory neuropathy grade 3 to grade 4 |
|||
|
Patients aged <60 years |
39 (1.5) |
15 (2.7) |
54 (1.7) |
|
Patients aged 60 to 64 years |
16 (3.1) |
2 (1.7) |
18 (2.8) |
|
Patients aged >64 years |
6 (1.8) |
3 (3.8) |
9 (2.2) |
|
P value |
0.050 |
0.662 |
0.177 |
|
Conjunctivitis grade 1 to grade 3 |
|||
|
Patients aged <60 years |
1,002 (46.1) |
- |
1,002 (46.1) |
|
Patients aged 60 to 64 years |
191 (45.9) |
- |
191 (45.9) |
|
Patients aged >64 years |
119 (45.9) |
- |
119 (45.9) |
|
P value |
0.996 |
- |
0.996 |
|
Conjunctivitis grade 3 |
|||
|
Patients aged <60 years |
25 (1.2) |
- |
25 (1.2) |
|
Patients aged 60 to 64 years |
7 (1.7) |
- |
7 (1.7) |
|
Patients aged >64 years |
4 (1.5) |
- |
4 (1.5) |
|
P value |
0.615 |
- |
0.615 |
|
Nail changes grade 1 to grade 3 |
|||
|
Patients aged <60 years |
849 (39.1) |
- |
849 (39.1) |
|
Patients aged 60 to 64 years |
171 (41.3) |
- |
171 (41.3) |
|
Patients aged >64 years |
100 (38.8) |
- |
100 (38.8) |
|
P value |
0.680 |
- |
0.680 |
|
Nail changes grade 3 |
|||
|
Patients aged <60 years |
22 (1.0) |
- |
22 (1.0) |
|
Patients aged 60 to 64 years |
6 (1.4) |
- |
6 (1.4) |
|
Patients aged >64 years |
1 (0.4) |
- |
1 (0.4) |
|
P value |
0.411 |
- |
0.411 |
|
Skin changes grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,126 (44.1) |
202 (36.1) |
1,328 (42.7) |
|
Patients aged 60 to 64 years |
221 (42.9) |
51 (43.2) |
272 (43.0) |
|
Patients aged >64 years |
137 (40.8) |
25 (31.6) |
162 (39.0) |
|
P value |
0.479 |
0.212 |
0.348 |
|
Skin changes grade 3 to grade 4 |
|||
|
Patients aged <60 years |
43 (1.7) |
4 (0.7) |
47 (1.5) |
|
Patients aged 60 to 64 years |
19 (3.7) |
2 (1.7) |
21 (3.3) |
|
Patients aged >64 years |
12 (3.6) |
0 (0.0) |
12 (2.9) |
|
P value |
0.003 |
0.388 |
0.003 |
|
Diarrhea grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,037 (40.6) |
137 (24.5) |
1,174 (37.7) |
|
Patients aged 60 to 64 years |
219 (42.2) |
30 (25.4) |
249 (39.3) |
|
Patients aged >64 years |
171 (50.6) |
13 (16.5) |
184 (44.1) |
|
P value |
0.002 |
0.263 |
0.039 |
|
Diarrhea grades 3 to grade 4 |
|||
|
Patients aged <60 years |
99 (3.9) |
7 (1.3) |
106 (3.4) |
|
Patients aged 60 to 64 years |
24 (4.7) |
0 (0.0) |
24 (3.8) |
|
Patients aged >64 years |
17 (5.0) |
0 (0.0) |
17 (4.1) |
|
P value |
0.482 |
0.288 |
0.731 |
|
Fluid retention grade 1 to grade 4 |
|||
|
Patients aged <60 years |
954 (37.4) |
- |
954 (37.4) |
|
Patients aged 60 to 64 years |
188 (36.5) |
- |
188 (36.5) |
|
Patients aged >64 years |
128 (38.0) |
- |
128 (38.0) |
|
P value |
0.898 |
- |
0.898 |
|
Fluid retention grade 3 to grade 4 |
|||
|
Patients aged <60 years |
42 (1.6) |
- |
42 (1.6) |
|
Patients aged 60 to 64 years |
7 (1.4) |
- |
7 (1.4) |
|
Patients aged >64 years |
4 (1.2) |
- |
4 (1.2) |
|
P value |
0.754 |
- |
0.754 |
|
Infection with neutropenia grade 1 to grade 4 |
|||
|
Patients aged <60 years |
174 (16.7) |
36 (6.4) |
210 (13.1) |
|
Patients aged 60 to 64 years |
48 (19.4) |
15 (12.5) |
63 (17.2) |
|
Patients aged >64 years |
35 (21.0) |
3 (3.8) |
38 (15.4) |
|
P value |
0.305 |
0.029 |
0.104 |
|
Infection with neutropenia grade 3 to grade 4 |
|||
|
Patients aged <60 years |
21 (2.0) |
4 (0.7) |
25 (1.6) |
|
Patients aged 60 to 64 years |
9 (3.6) |
3 (2.5) |
12 (3.3) |
|
Patients aged >64 years |
8 (4.8) |
2 (2.5) |
10 (4.1) |
|
P value |
0.062 |
0.129 |
0.010 |
|
Creatinine grade 1 to grade 4 |
|||
|
Patients aged <60 years |
73 (3.4) |
7 (1.3) |
80 (3.0) |
|
Patients aged 60 to 64 years |
26 (6.3) |
5 (4.2) |
31 (5.8) |
|
Patients aged >64 years |
20 (7.8) |
5 (7.0) |
25 (7.6) |
|
P value |
<0.001 |
0.003 |
<0.001 |
|
Hot flushes grade 1 to grade 3 |
|||
|
Patients aged <60 years |
425 (64.6) |
- |
425 (64.6) |
|
Patients aged 60 to 64 years |
88 (59.1) |
- |
88 (59.1) |
|
Patients aged >64 years |
46 (51.1) |
- |
46 (51.1) |
|
P value |
0.031 |
- |
0.031 |
|
Hot flushes grade 3 |
|||
|
Patients aged <60 years |
66 (10.0) |
- |
66 (10.0) |
|
Patients aged 60 to 64 years |
15 (10.1) |
- |
15 (10.1) |
|
Patients aged >64 years |
2 (2.2) |
- |
2 (2.2) |
|
P value |
0.053 |
- |
0.053 |
|
Liver enzymes grade 1 to grade 4 |
|||
|
Patients aged <60 years |
1,198 (47.2) |
447 (82.8) |
1,645 (53.5) |
|
Patients aged 60 to 64 years |
193 (42.0) |
95 (84.1) |
288 (50.3) |
|
Patients aged >64 years |
111 (35.7) |
53 (74.6) |
164 (42.9) |
|
P value |
<0.001 |
0.206 |
<0.001 |
|
Liver enzymes grade 3 to grade 4 |
|||
|
Patients aged <60 years |
48(1.9) |
65 (12.0) |
113 (3.7) |
|
Patients aged 60 to 64 years |
12 (2.6) |
10 (8.8) |
22 (3.8) |
|
Patients aged >64 years |
7 (2.3) |
0 (0.0) |
7 (1.8) |
|
P value |
0.574 |
0.006 |
0.166 |
|
|
|||
|
Data presented as n (%). All percentage values are valid. |
|||
|
Loibl et al. Breast Cancer Research 2008 10:R77 doi:10.1186/bcr2144 |
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