Table 3 |
||||||
|
Correlation betweeen HMGCoAR expression and clinicopathological parameters in oestrogen receptor (ER) positive and ER-negative tumours. |
||||||
| ER-positive |
ER-negative |
|||||
|
|
||||||
| HMG-CoAR intensity |
0 |
1–3 |
0 |
1–3 |
||
| n (%) |
88 (23) |
294 (77) |
p value |
22 (38) |
36 (62) |
p value |
|
|
||||||
| Age (years) |
||||||
| Median |
66 |
65 |
57 |
59 |
||
| Range |
28–89 |
35–96 |
0.43 |
27–81 |
34–90 |
0.38 |
| ≤50 |
15 (17) |
45 (15) |
7 (32) |
8 (27) |
||
| >50 |
73 (83) |
249 (85) |
0.69 |
15 (68) |
28 (73) |
0.42 |
| Tumour size |
||||||
| Median |
20 |
15 |
22 |
17 |
||
| Range |
1 to 100 |
1 to 100 |
<0.001 |
12 to 55 |
1 to 100 |
0.10 |
| ≥20 mm |
48 (55) |
147 (60) |
9 (41) |
19 (53) |
||
| >20 mm |
40 (45) |
97 (40) |
0.03 |
13 (59) |
17 (47) |
0.38 |
| NHG |
||||||
| I |
11 (13) |
95 (32) |
0 |
1 (3) |
||
| II |
40 (45) |
126 (43) |
5 (23) |
9 (25) |
||
| III |
37 (42) |
72 (25) |
<0.001 |
17 (77) |
26 (72) |
0.56 |
| Node status |
||||||
| Negative |
48 (59) |
167 (64) |
19 (90) |
11 (36) |
||
| Positive |
33 (41) |
95 (36) |
0.47 |
2 (10) |
19 (63) |
<0.001 |
| Unknown |
7 |
32 |
1 |
6 |
||
| Tamoxifen |
||||||
| No |
41 (55) |
133 (60) |
8 (50) |
12 (44) |
||
| Yes |
33 (45) |
87 (40) |
0.45 |
8 (50) |
15 (56) |
0.73 |
| Unknown |
14 |
74 |
6 |
6 |
||
| Chemotherapy |
||||||
| No |
67 (91) |
214 (96) |
14 (88) |
23 (85) |
||
| Yes |
7 (9) |
8 (4) |
0.05 |
2 (12) |
4 (15) |
0.84 |
| Unknown |
14 |
72 |
6 |
6 |
||
| HER2 IHC |
||||||
| 0 |
59 (71) |
144 (51) |
17 (81) |
12 (34) |
||
| 1 |
13 (16) |
85 (30) |
0 |
5 (14) |
||
| 2 |
6 (7) |
35 (12) |
0 |
1 (3) |
||
| 3 |
5 (6) |
19 (7) |
0.02 |
4 (19) |
17 (49) |
0.007 |
| Unknown |
5 |
11 |
1 |
1 |
||
| HER2 IHC |
||||||
| 0 to 2 |
78 (94) |
264 (93) |
17 (80) |
18 (51) |
||
| 3 |
5 (6) |
19 (7) |
0.82 |
4 (20) |
17 (49) |
0.02 |
| Unknown |
5 |
11 |
1 |
1 |
||
| Ki67 |
||||||
| 0 to 10% |
27 (32) |
116 (42) |
1 (5) |
4 (12) |
||
| 11 to 25% |
32 (38) |
101 (37) |
3 (15) |
7 (21) |
||
| >25% |
25 (30) |
58 (21) |
0.05 |
16 (80) |
23 (68) |
0.30 |
| Unknown |
4 |
19 |
2 |
1 |
||
|
|
||||||
|
ER = oestrogen receptor; HER2 = human epidermal growth factor receptor 2; IHC = immunohistochemistry; NHG = Nottingham histological grade. 10% cut-off used for determination of hormone receptor status. Mann-Whitney test for comparison of medians and chi-squared test for X × 2 tables. The categories marked as not done and unknown were not included in the analysis. |
||||||
|
Borgquist et al. Breast Cancer Research 2008 10:R79 doi:10.1186/bcr2146 |
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