Table 4

EGFR and HER2 expression in primary tumor and in CTCs

Early disease
 Metastatic disease


Primary tumor
 CTCs
 Primary tumor
 CTCs

Patient number
 HER2
 EGFR
 HER2
 EGFR
 HER2
 EGFR
 HER2
 EGFR
1
 -
 +
 +
 +
 -
 -
 +
 -
2
 +a
 NA
 +
 -
 +
 -
 +
 -
3
 -
 -
 -
 +
 +
 NA
 +
 +
4
 -
 -
 +
 -
 -
 -
 -
 -
5
 -
 -
 +
 -
 -
 -
 +
 -
6
 -
 NA
 +
 +
 -
 NA
 -
 -
7
 -
 +
 -
 +
 +
 -
 +
 -
8
 -
 -
 -
 -
 -
 -
 +
 -
9
 +
 -
 -
 -
 -
 NA
 -
 -
10
 +
 -
 +
 +
 +
 -
 +
 +
11
 -
 +
 -
 -
 +
 NA
 -
 +
12
 -
 -
 +
 -
 -
 +
 -
 -
13
 -
 -
 +
 -
 -
 NA
 -
 +
14
 -
 -
 -
 -
 -
 -
 +
 +
15
 -
 NA
 -
 -
 -
 NA
 +
 +
16
 NA
 NA
 -
 +
 -
 -
 +
 +

aScore +3 or fluorescence in situ hybridization positive. CTC, circulating tumor cell; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor.

Kallergi et al. Breast Cancer Research 2008 10:R80   doi:10.1186/bcr2149

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