Table 1 |
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|
Fraction of tumors showing CCND1 amplification (FISH) in subgroups defined by expression of the 11q proteins |
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| Cortactin |
FADD |
Cyclin D1 |
Pak1 |
Chk1 fraction positive nuclei (%) |
Chk1/Ki67 ratio |
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|
|
|
||||||||
| 0 to 5 |
6 to 50 |
51 to 100 |
Deviant |
Normal |
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|
|
|||||||||
| CCND1 amplified (%) |
14.6 |
12.6 |
15.9 |
16.3 |
24.2 |
15.3 |
0 |
34.8 |
14.8 |
| Amplified and overexpessing (%) |
44.0 |
41.7 |
31.8 |
28.9 |
|||||
| P value |
0.020 |
0.002 |
<0.001 |
0.008 |
0.010 |
0.034 |
|||
|
|
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|
P values for correlations between expression of the 11q gene products and CCND1 amplification are indicated in the bottom row. Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; FISH, fluorescence in situ hybridization; Pak1, p21-activated kinase 1. |
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|
Lundgren et al. Breast Cancer Research 2008 10:R81 doi:10.1186/bcr2150 |
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