Table 3 |
|||||
|
Distribution of 11q protein staining category in relation to CGH gene profile |
|||||
|
Protein expression |
Gene expression |
||||
|
Deletion |
Normal |
Gain/Amp |
Total |
P valuea |
|
|
|
|||||
|
Cortactin |
0.664 |
||||
|
Low/intermediate expression |
1 |
13 |
5 |
19 |
|
|
Over-expression |
0 |
6 |
3 |
9 |
|
|
Total |
1 |
19 |
8 |
28 |
|
|
|
|||||
|
FADD |
0.477 |
||||
|
Low/intermediate expression |
0 |
16 |
7 |
23 |
|
|
Over-expression |
0 |
3 |
3 |
6 |
|
|
Total |
0 |
19 |
10 |
29 |
|
|
|
|||||
|
Cyclin D1 |
0.083 |
||||
|
Low/intermediate expression |
3 |
30 |
10 |
43 |
|
|
Over-expression |
0 |
1 |
3 |
4 |
|
|
Total |
3 |
31 |
13 |
47 |
|
|
|
|||||
|
Pak1 |
0.027 |
||||
|
Negative |
3 |
28 |
4 |
35 |
|
|
Positive |
0 |
4 |
5 |
9 |
|
|
Total |
3 |
32 |
9 |
44 |
|
|
|
|||||
|
Chk1 |
0.241b |
||||
|
0% to 5% (low) |
2 |
6 |
0 |
8 |
|
|
6% to 50% (intermediate) |
5 |
18 |
0 |
23 |
|
|
51% to 100% (high) |
0 |
7 |
0 |
7 |
|
|
Total |
7 |
31 |
0 |
38 |
|
|
|
|||||
|
aCorrelations were calculated using Mann-Whitney test (two-sided) unless otherwise specified. bSpearman's ρ. Amp, amplification; CGH, comparative genomic hybridization; Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; Pak1, p21-activated kinase 1. |
|||||
|
Lundgren et al. Breast Cancer Research 2008 10:R81 doi:10.1186/bcr2150 |
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