Figure 6.

DKK3 protein expression in primary breast carcinomas as determined by immunohistochemical staining. (a) Normal mammary tissue without (left) and with application (right) of DKK3 antibody. Abundant DKK3 protein expression is detectable in luminal and basal epithelial cells. (b) Breast carcinoma with unmethylated DKK3 promoter reveals abundant DKK3 protein expression. (c) and (d) Breast carcinomas with a methylated DKK3 promoter exhibit substantial loss of DKK3 protein expression. Original magnifications are given in upper right-hand corner.