Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma

Nadia P Castro1, Cynthia ABT Osório2, César Torres3, Elen P Bastos1, Mário Mourão-Neto4, Fernando A Soares2, Helena P Brentani3 and Dirce M Carraro1*

Author Affiliations

1 Laboratório de Genômica e Biologia Molecular, Centro de Pesquisa Hospital do Câncer A C Camargo, CEP: 01509-900, São Paulo, SP, Brazil

2 Departamento de Anatomia Patológica, Centro de Pesquisa Hospital do Câncer A C Camargo, CEP: 01509-900, São Paulo, SP, Brazil

3 Laboratório de Bioinformática, Centro de Pesquisa Hospital do Câncer A C Camargo, CEP: 01509-900, São Paulo, SP, Brazil

4 Departamento de Mastologia, Hospital do Câncer A C Camargo, CEP: 01509-900, São Paulo, SP, Brazil

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Breast Cancer Research 2008, 10:R87 doi:10.1186/bcr2157


See related editorial by Schnitt, http://breast-cancer-research.com/content/11/1/101

Published: 17 October 2008

Additional files

Additional file 1:

Differentially expressed genes: non-neoplastic, pure DCIS, in situ component of DCIS-IDC, and IDC lesions. Presented is a table listing the differentially expressed genes among cells from non-neoplastic, pure DCIS, in situ component of DCIS-IDC, and IDC lesions.

Format: PDF Size: 61KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 2:

Differentially expressed genes: pure DCIS, in situ component of DCIS-IDC, and IDC lesions. Presented is a table listing the differentially expressed genes among tumor cells from pure DCIS, in situ component of DCIS-IDC, and IDC lesions.

Format: PDF Size: 13KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

Differentially expressed genes: non-neoplastic, pure DCIS, and in situ component of DCIS-IDC lesions. Presented is a table listing the differentially expressed genes among cells from non-neoplastic, pure DCIS, and in situ component of DCIS-IDC lesions.

Format: PDF Size: 61KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

Differentially expressed genes resulting from of 2 × 2 comparisons. Presented is a table listing the differentially expressed genes resulting from of 2 × 2 comparisons: non-neoplastic × pure DICS; non-neoplastic × in situ component of DCIS-IDC; and pure DCIS × in situ component of DCIS-IDC.

Format: PDF Size: 26KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

147 Genes differentially expressed between pure DCIS and in situ component of DCIS-IDC. Presented a table listing the 147 genes differentially expressed between pure DCIS and in situ component of DCIS-IDC with the respective fold changes.

Format: PDF Size: 21KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data