Table 2 |
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|
Cox univariate regression comparing the random forest clustering (RFC) thresholds for the oestrogen receptor (ER) and the progesterone receptor (PR) with both the manual analysis and the 10% cutoff thresholds of the quantitative data |
|||||||||
| Manual analysis threshold |
10% automated threshold |
RFC threshold |
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|
|
|
|
|||||||
| HR |
95% CI |
P value |
HR |
95% CI |
P value |
HR |
95% CI |
P value |
|
|
|
|||||||||
| Cohort I (n = 179) |
|||||||||
| ER |
|||||||||
| OS |
0.259 |
0.127 to 0.530 |
0.001 |
0.154 |
0.067 to 0.355 |
0.002 |
0.235 |
0.116 to 0.473 |
0.001 |
| PR |
|||||||||
| OS |
0.307 |
0.158 to 0.597 |
0.001 |
0.361 |
0.183 to 0.712 |
0.01 |
0.386 |
0.197 to 0.756 |
0.02 |
| Cohort II (n = 564) |
|||||||||
| ER |
|||||||||
| OS |
0.62 |
0.465 to 0.826 |
0.006 |
0.68 |
0.509 to 0.907 |
0.009 |
0.631 |
0.480 to 0.830 |
0.001 |
| BCSS |
0.677 |
0.494 to 0.928 |
0.006 |
0.664 |
0.492 to 0.898 |
0.008 |
0.592 |
0.445 to 0.787 |
< 0.001 |
| RFS |
0.714 |
0.540 to 0.943 |
0.009 |
0.797 |
0.603 to 1.054 |
0.11 |
0.701 |
0.538 to 0.914 |
0.009 |
| PR |
|||||||||
| OS |
0.647 |
0.483 to 0.867 |
0.004 |
0.719 |
0.538 to 0.961 |
0.026 |
0.705 |
0.524 to 0.947 |
0.020 |
| BCSS |
0.602 |
0.445 to 0.814 |
0.001 |
0.7 |
0.518 to 0.947 |
0.020 |
0.673 |
0.495 to 0.916 |
0.012 |
| RFS |
0.73 |
0.549 to 0.972 |
0.03 |
0.797 |
0.603 to 1.053 |
0.790 |
0.791 |
0.593 to 1.054 |
0.109 |
|
|
|||||||||
|
HR, hazard ratio; CI, confidence interval; OS, overall survival; BCSS, breast cancer-specific survival; RFS, recurrence-free survival. |
|||||||||
|
Rexhepaj et al. Breast Cancer Research 2008 10:R89 doi:10.1186/bcr2187 |
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