Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype

Changhua Zhou1,2, Ashley M Nitschke3,4,5, Wei Xiong5,6, Qiang Zhang1, Yan Tang4,7,5,6, Michael Bloch3,4,5, Steven Elliott3,4, Yun Zhu3, Lindsey Bazzone3, David Yu7,8, Christopher B Weldon8, Rachel Schiff9, John A McLachlan4,6, Barbara S Beckman4,6, Thomas E Wiese10, Kenneth P Nephew11, Bin Shan3,4,5, Matthew E Burow3,4,7,5,6* and Guangdi Wang1*

Author Affiliations

1 Department of Chemistry, Xavier University of Louisiana, New Orleans, LA 70125, USA

2 Chengdu Blood Center, Chengdu, Sichuan 610041, PR China

3 Department of Medicine, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA 70112, USA

4 Center for Bioenvironmental Research at Tulane and Xavier Universities, Tulane Avenue, New Orleans, LA 70112, USA

5 Tulane Cancer Center, Tulane Avenue, New Orleans, LA 70112, USA

6 Department of Pharmacology, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA 70112, USA

7 Department of Surgery, Tulane University School of Medicine, Tulane Avenue, New Orleans, LA 70112, USA

8 Department of Surgery, Children's Hospital Boston, Longwood Avenue, Boston, MA 02115, USA

9 The Dan L Duncan Cancer Center, Baylor College of Medicine, Baylor Plaza, Houston, TX 77030, USA

10 College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, USA

11 Medical Sciences, Indiana University School of Medicine, East 3rd Street, Bloomington, IN 47405-4401, USA

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Breast Cancer Research 2008, 10:R105 doi:10.1186/bcr2210

Published: 16 December 2008

Additional files

Additional file 1:

A Word file containing a table listing the primer sequences used in all RT-PCR experiments.

Format: DOC Size: 50KB Download file

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Additional file 2:

A Word file containing a table listing all identified proteins that were differentially expressed in MCF-7-MEK5 versus MCF-7-VEC breast cancer cells.

Format: DOC Size: 133KB Download file

This file can be viewed with: Microsoft Word Viewer

Open Data