Breast Cancer Research

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Open Access Highly Access Research article

EZH2 and BMI1 inversely correlate with prognosis and TP53 mutation in breast cancer

Alexandra M Pietersen1,2†, Hugo M Horlings3†, Michael Hauptmann4, Anita Langerød5, Abderrahim Ajouaou3, Paulien Cornelissen-Steijger1, Lodewijk F Wessels4, Jos Jonkers4, Marc J Vijver6 and Maarten van Lohuizen1*

Author Affiliations

1 Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066X, The Netherlands

2 Current address: Division of Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, 169610, Singapore

3 Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066X, The Netherlands

4 Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066X, The Netherlands

5 Department of Genetics, Institute for Cancer Research, Norwegian Radium Hospital, Rikshospitalet University Hospital, Ullernchausèen 70, Motebello 0310, Oslo, Norway

6 Department of Pathology, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands

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Breast Cancer Research 2008, 10:R109 doi:10.1186/bcr2214

Published: 19 December 2008

Additional files

Additional file 1:

PDF file containing a figure that shows that Miller's TP53 signature also identifies more TP53 mutations in high EZH2 breast tumours.

Format: PDF Size: 46KB Download file

This file can be viewed with: Adobe Acrobat Reader

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