Table 2

Descriptive statistics of studies in the meta-analysis

Study

Total n

Subset

Survivin

Notch-1

Keratin 5

Mean

SEM

P

Mean

SEM

P

Mean

SEM

P

Chin and colleagues [55]

118

ER- (n = 43)

0.7723

0.0815

1.353 × 10^-5

0.7793

0.0548

2.231 × 10^-5

0.9844

0.1436

4.893 × 10^-6

ER+ (n = 75)

0.3371

0.0437

0.5027

0.0245

0.1884

0.0678

Desmedt and colleagues [56]

198

ER- (n = 64)

0.7238

0.0478

1.414 × 10^-8

0.3254

0.0389

3.951 × 10^-4

0.6649

0.0996

1.159 × 10^-2

ER+ (n = 134)

0.3278

0.0460

0.1658

0.0193

0.3773

0.0507

Ginestier and colleagues [57]

55

ER- (n = 28)

0.7621

0.1251

9.689 × 10^-5

1.4343

0.0504

2.933 × 10^-4

1.2587

0.2116

1.219 × 10^-2

ER+ (n = 27)

0.4959

0.0954

1.1536

0.0520

0.5842

0.1492

Hess and colleagues [58]

133

ER- (n = 51)

0.0776

0.0451

2.071 × 10^-3

0.2169

0.0454

1.203 × 10^-1

0.5110

0.1706

1.165 × 10^-4

ER+ (n = 82)

-0.0956

0.0309

0.1238

0.0384

-0.2216

0.0480

Ivshina and colleagues [59]

249^a

ER- (n = 34)

0.4877

0.0847

1.064e × 10^-7

0.3819

0.0589

1.643 × 10^-2

0.7071

0.1683

1.403 × 10^-1

ER+ (n = 211)

-0.0950

0.0408

0.2299

0.0137

0.4438

0.0479

Miller and colleagues [60]

251

ER- (n = 34)

0.3701

0.0681

2.780 × 10^-8

0.3011

0.0443

2.073 × 10^-2

0.4714

0.1310

2.638 × 10^-1

ER+ (n = 213)

-0.1337

0.0382

0.1905

0.0113

0.3165

0.0389

Minn and colleagues [61]

82

ER- (n = 42)

0.1969

0.0719

1.809 × 10^-4

0.4515

0.0529

7.897 × 10^-5

1.1060

0.1311

2.391 × 10^-6

ER+ (n = 57)

-0.1821

0.0652

0.2036

0.0247

0.2624

0.1028

Richardson and colleagues [62]

39

ER- (n = 24)

-0.1141

0.1363

6.374 × 10^-3

1.1360

0.0621

1.216 × 10^-1

1.1878

0.1436

4.670e × 10^-3

ER+ (n = 15)

-0.6187

0.1089

1.0139

0.0457

0.6193

0.1225

Saal and colleagues [37]

105

ER- (n = 60)

-1.3798

0.1075

5.143 × 10^-6

0.2043

0.0756

3.033 × 10^-3

ER+ (n = 45)

-2.1290

0.1121

-0.1145

0.0728

Sotiriou and colleagues [63]

119

ER- (n = 34)

0.4834

0.0320

2.528 × 10^-3

0.2702

0.0565

1.323 × 10^-4

0.9849

0.1107

9.396 × 10^-3

ER+ (n = 85)

0.3691

0.0166

0.0181

0.0196

0.6560

0.0499

Turashvili [32]

10

ER- (n = 3)

0.1268

0.1688

2.533 × 10^-1

1.1991

0.1243

3.082 × 10^-1

0.6117

0.3735

6.750 × 10^-1

ER+ (n = 7)

-0.2686

0.2733

1.0239

0.0709

0.3655

0.4358

van de Vijver and colleagues [64]

295

ER- (n = 69)

0.3719

0.2218

1.847 × 10^-12

0.6277

0.1148

1.418 × 10^-10

-0.7917

0.4073

1.748 × 10^-5

ER+ (n = 226)

-1.7301

0.1580

-0.2900

0.0590

-2.8083

0.1822

Wang and colleagues [65]

286

ER- (n = 77)

0.0902

0.0459

2.284 × 10^-8

0.4139

0.0282

2.255 × 10^-11

0.8906

0.0819

3.242 × 10^-7

ER+ (n = 209)

-0.2387

0.0318

0.1784

0.0151

0.3844

0.0459

Yu and colleagues [38]

68 (19)

ER- (n = 15)

-0.2546

0.0874

1.689 × 10^-1

-0.2712

0.1090

1.946 × 10^-4

1.8394*

0.2312*

2.280 × 10^-2 *

ER+ (n = 4)

-0.4225

0.0831

0.7625

0.0431

0.9196*

0.2431*

Zhao and colleagues (lobular) [36]

16

ER- (n = 4)

-2.4418

0.2721

6.851 × 10^-1

0.0416

0.4079

7.011 × 10^-1

ER+ (n = 12)

-2.3108

0.1269

-0.1367

0.1083

Zhao and colleagues (ductal) [36]

34

ER- (n = 11)

-1.4613

0.2938

1.440 × 10^-1

0.3298

0.3722

1.769 × 10^-1

ER+ (n = 23)

-2.0013

0.1981

-0.2272

0.1104

Mean, standard error of mean (SEM), and P value between estrogen receptor-negative (ER-) and estrogen receptor-positive (ER+) breast cancers are presented for Notch-1, survivin, and keratin-5 expression in the analyzed datasets. ^aUppsala cohort. * Subset of samples with keratin-5 data.

Lee et al. Breast Cancer Research 2008 10:R97   doi:10.1186/bcr2200