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Table 6
Odds ratios (OR) and 95% confidence intervals (CI)^abetween LUM SNP rs2268578 and breast cancer risk, stratified by tumor estrogen receptor status among 1,641 Caucasian subjects (Mayo Clinic 2001 to 2005) and 9,030 Caucasian subjects (SEARCH study 1990 to 2005)^b
	Estrogen receptor-positive					Estrogen receptor-negative

Model	Mayo Clinic sample		SEARCH sample		Pooled Mayo Clinic + SEARCH sample	Mayo Clinic sample		SEARCH sample		Pooled Mayo Clinic + SEARCH sample

	Cases/controls	OR (95% CI)	Cases/controls	OR (95% CI)	OR (95% CI)	Cases/controls	OR (95% CI)	Cases/controls	OR (95% CI)	OR (95% CI)

General
0 copy	340/661	1.0 (referent)	1,506/3,506	1.0 (referent)	1.0 (referent)	86/661	1.0 (referent)	344/3,506	1.0 (referent)	1.0 (referent)
1 copy	125/167	1.5 (1.1 to 1.9)	431/980	1.0 (0.9 to 1.1)	1.1 (0.9 to 1.2)	20/167	0.9 (0.5 to 1.5)	107/980	1.0 (0.8 to 1.4)	1.0 (0.8 to 1.3)
2 copies	17/13	2.5 (1.2 to 5.3)	47/62	1.6 (1.0 to 2.5)	1.9 (1.3 to 2.8)	3/13	1.7 (0.4 to 6.5)	5/62	0.8 (0.3 to 2.0)	1.0 (0.5 to 2.2)
P value^c		0.001		0.10	0.001		0.67		0.79	0.98
Ordinal		1.5 (1.2 to 1.9)		1.1 (0.9 to 1.2)	1.1 (1.0 to 1.3)		1.0 (0.7 to 1.6)		1.0 (0.8 to 1.3)	1.0 (0.8 to 1.2)
P trend		0.0003		0.29	0.01		0.89		0.93	0.86

^aMayo sample adjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota); SEARCH sample adjusted for age; pooled Mayo + SEARCH sample adjusted for age and study. ^b798 cases and 843 controls (Mayo Clinic sample), and 4,470 cases and 4,560 controls (SEARCH sample). Numbers do not total due to missing tumor status: 1,985 (44%) in SEARCH and 206 (26%) in Mayo Clinic sample. ^cTwo-degrees-of-freedom test.
Kelemen et al. Breast Cancer Research 2008 10:R98 doi:10.1186/bcr2201

Table 6