Ultra-small iron particle-enhanced magnetic resonance imaging of axillary lymph nodes in breast cancer

doi:10.1186/bcr2001

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Objective
Methods
Results
Conclusion

Breast Cancer Research

Volume 10
Suppl 3

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This article is part of the supplement: Symposium Mammographicum 2008 .

Oral presentation

Ultra-small iron particle-enhanced magnetic resonance imaging of axillary lymph nodes in breast cancer

TH Helbiech

Department of Medical Imaging, UHN/MSH/WCH, University of Toronto, Princess Margaret Hospital, Toronto, Canada

from Symposium Mammographicum 2008
Lille, France. 6–8 July 2008

Breast Cancer Research 2008, 10(Suppl 3):P3doi:10.1186/bcr2001

The electronic version of this abstract is the complete one and can be found online at: http://breast-cancer-research.com/content/10/S3/P3

Published:

7 July 2008

Objective

To report the diagnostic value of ultra-small iron particle (USPIO)-enhanced magnetic resonance imaging (MRI) in the detection of axillary lymph node metastases in patients with breast carcinomas.

Methods

Patients with breast carcinomas were enrolled in a prospective phase III study. MRI of the axilla was performed at 1 Tesla prior to and 24 to 36 hours after intravenous administration of USPIO (Sinerem^®; Guerbet, France). MRI sequences were performed pre and post USPIO administration (axial T1 3D FFE, axial and sagittal T2* FFE, and T2 TSE). Imaging results were compared with histopathologic findings.

Results

A total of 154 lymph nodes were detected equally by pre and post USPIO-MRI. USPIO-MRI revealed a node-by-node sensitivity, specificity, and accuracy of 92%, 99%, and 98%, respectively. USPIO-enhanced MRI did not miss any lymph node metastases in a patient-by-patient correlation.

Conclusion

USPIO-MRI is a valuable method in the assessment of axillary lymph node metastases in patients with breast carcinomas and has potential as a noninvasive sentinel lymph node technique.

This article is part of the supplement: Symposium Mammographicum 2008 .

Ultra-small iron particle-enhanced magnetic resonance imaging of axillary lymph nodes in breast cancer

Objective

Methods

Results

Conclusion

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