Breast Cancer Research

official impact factor 5.79

Open Access Highly Access Research article

CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines

Gwladys Zabouo1,2, Anne-Marie Imbert1,2*, Jocelyne Jacquemier3,4, Pascal Finetti4, Thomas Moreau1,2, Benjamin Esterni2, Daniel Birnbaum4, François Bertucci2,4,5,6 and Christian Chabannon1,2,6,7

Author Affiliations

1 Institut Paoli-Calmettes, Centre de Ressources Biologiques en Oncologie, Centre de Thérapie Cellulaire et Génique, Marseille 13009, France

2 Inserm U891, Centre de Recherche en Cancérologie de Marseille, Equipe Recherche Clinique, Marseille 13009, France

3 Institut Paoli-Calmettes, Département de Bio-pathologie, Marseille 13009, France

4 Inserm U891, Centre de Recherche en Cancérologie de Marseille, Equipe Oncologie Moléculaire, Marseille 13009, France

5 Institut Paoli-Calmettes, Département de Médecine, Marseille 13009, France

6 Université de la Méditerranée, Marseille 13007, France

7 Inserm CIC-B510, Centre d'Investigations Cliniques en Biothérapie, Marseille 13009, France

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Breast Cancer Research 2009, 11:R1 doi:10.1186/bcr2215

Published: 5 January 2009

Additional files

Additional file 1:

A Word file containing information about the mAbs used in the present study.

Format: DOC Size: 44KB Download file

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Additional file 2:

A Word file containing information about the sequences of primers used in quantitative RT-PCR and sequences of siRNAs and shRNAs.

Format: DOC Size: 76KB Download file

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Additional file 3:

A Word file containing a table that presents the genes tested by quantitative RT-PCR.

Format: DOC Size: 223KB Download file

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Additional file 4:

A Word file containing a table that presents the genes of the stromal cluster.

Format: DOC Size: 103KB Download file

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Additional file 5:

An Adobe file containing a figure showing the downmodulation of CD146 in MDA-MB-231 cells with shRNAs targeting CD146.

Format: PDF Size: 30KB Download file

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Additional file 6:

An Adobe file containing a figure showing the mRNA expression levels between the wild-type and the mock-transfected MDA-MB-231 cell lines displayed as a volcano plot.

Format: PDF Size: 52KB Download file

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Open Data